BAIT
NTRK2
GP145-TrkB, TRKB, trk-B, RP11-263K15.1
neurotrophic tyrosine kinase, receptor, type 2
GO Process (18)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- activation of adenylate cyclase activity [TAS]
- brain-derived neurotrophic factor receptor signaling pathway [IMP]
- central nervous system neuron development [ISS]
- cerebral cortex development [ISS]
- learning [ISS]
- negative regulation of neuron apoptotic process [ISS]
- neuron differentiation [ISS]
- neuron migration [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of MAPK cascade [ISS]
- positive regulation of axonogenesis [ISS]
- positive regulation of cell proliferation [ISS]
- positive regulation of gene expression [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- protein autophosphorylation [ISS]
- regulation of Rac GTPase activity [ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SH2B1
PSM, SH2B
SH2B adaptor protein 1
GO Process (1)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor.
Brain-derived neurotrophic factor (BDNF) binds to and activates the TrkB tyrosine kinase receptor to regulate cell differentiation, survival, and neural plasticity in the nervous system. However, the identities of the downstream signaling proteins involved in this process remain unclear. Using a yeast two-hybrid screen with the intracellular domain (ICD-TrkB) of the TrkB BDNF receptor, we identified the Nck2 adaptor protein ... [more]
Biochem. Biophys. Res. Commun. Jun. 28, 2002; 294(5);1087-92 [Pubmed: 12074588]
Throughput
- Low Throughput
Curated By
- BioGRID