VCAM1
Gene Ontology Biological Process
- B cell differentiation [IC]
- amine metabolic process [IDA]
- cell adhesion [IDA]
- cell-matrix adhesion [IDA]
- cytokine-mediated signaling pathway [TAS]
- extracellular matrix organization [TAS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte cell-cell adhesion [IDA]
- leukocyte tethering or rolling [IDA, IEP]
- membrane to membrane docking [IEP]
- oxidation-reduction process [IDA]
- positive regulation of T cell proliferation [IDA]
- regulation of immune response [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex [IDA]
- apical part of cell [IDA]
- cell surface [IDA]
- early endosome [IDA]
- endoplasmic reticulum [IDA]
- external side of plasma membrane [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- filopodium [IDA]
- microvillus [IDA]
- plasma membrane [TAS]
- podosome [IDA]
CCL22
Gene Ontology Biological Process
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Quantitative differences in chemokine receptor engagement generate diversity in integrin-dependent lymphocyte adhesion.
Chemokines control the specificity of lymphocyte homing. Numerous chemokines have been identified but the significance of redundancy in chemokine networks is unexplained. Here we investigated the biological significance of distinct chemokines binding to the same receptor. Among CCR4 ligands, skin vessels endothelial cells present C-C chemokine ligand (CCL) 17 but not CCL22 consistent with CCL17 involvement in T lymphocyte arrest ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID