PXN
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- branching morphogenesis of an epithelial tube [IDA]
- cellular component movement [IMP]
- cytoskeleton organization [IMP]
- focal adhesion assembly [IDA]
- growth hormone receptor signaling pathway [ISO]
- integrin-mediated signaling pathway [IMP, TAS]
- lamellipodium assembly [IDA]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of protein kinase activity [IMP]
- regulation of cell shape [IMP]
- substrate adhesion-dependent cell spreading [IMP]
- transforming growth factor beta receptor signaling pathway [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ARHGEF7
Gene Ontology Biological Process
- astrocyte cell migration [ISO]
- focal adhesion assembly [ISO]
- hematopoietic progenitor cell differentiation [IGI]
- lamellipodium assembly [IMP]
- positive regulation of GTPase activity [ISO]
- positive regulation of Rac GTPase activity [IMP, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of fibroblast migration [ISO]
- positive regulation of lamellipodium morphogenesis [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- small GTPase mediated signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Hic-5 interacts with GIT1 with a different binding mode from paxillin.
Hic-5, a member of the paxillin family of adaptor molecules, is localized at focal adhesion and implicated in integrin-mediated signaling. Hic-5 and paxillin exhibit structural homology and share interacting factors, however, diverse functions are suggested for them. In this study, we carried out yeast two-hybrid screening to identify Hic-5 interacting factors using its LD3-4 region, which includes the Hic-5-specific amino ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID