BAIT
IL1B
IL-1, IL1-BETA, IL1F2
interleukin 1, beta
GO Process (60)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- MAPK cascade [IMP]
- activation of MAPK activity [IDA]
- apoptotic process [TAS]
- cell-cell signaling [TAS]
- cellular response to drug [IDA]
- cellular response to mechanical stimulus [IEP]
- cellular response to organic cyclic compound [IDA]
- cellular response to organic substance [IDA]
- cytokine-mediated signaling pathway [IDA]
- embryo implantation [TAS]
- hyaluronan biosynthetic process [IDA]
- inflammatory response [IDA, NAS]
- lipopolysaccharide-mediated signaling pathway [IDA]
- monocyte aggregation [IDA]
- negative regulation of MAP kinase activity [ISS]
- negative regulation of adiponectin secretion [ISS]
- negative regulation of cell proliferation [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- negative regulation of glucose transport [ISS]
- negative regulation of insulin receptor signaling pathway [ISS]
- negative regulation of lipid catabolic process [IDA]
- negative regulation of lipid metabolic process [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IBA]
- positive regulation of JNK cascade [IBA]
- positive regulation of NF-kappaB import into nucleus [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of T cell mediated immunity [IC]
- positive regulation of T cell proliferation [IDA]
- positive regulation of angiogenesis [ISS]
- positive regulation of calcidiol 1-monooxygenase activity [IDA]
- positive regulation of cell adhesion molecule production [NAS]
- positive regulation of fever generation [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of granulocyte macrophage colony-stimulating factor production [IDA]
- positive regulation of heterotypic cell-cell adhesion [IDA, NAS]
- positive regulation of histone acetylation [NAS]
- positive regulation of histone phosphorylation [NAS]
- positive regulation of interferon-gamma production [IDA]
- positive regulation of interleukin-2 biosynthetic process [IMP]
- positive regulation of interleukin-6 production [TAS]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of lipid catabolic process [ISS]
- positive regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of mitosis [IMP]
- positive regulation of monocyte chemotactic protein-1 production [IDA]
- positive regulation of myosin light chain kinase activity [IDA]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of prostaglandin secretion [ISS]
- positive regulation of protein export from nucleus [NAS]
- positive regulation of protein phosphorylation [IDA, NAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IC]
- positive regulation vascular endothelial growth factor production [IDA, ISS]
- protein kinase B signaling [IMP]
- regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- regulation of insulin secretion [IDA]
- sequestering of triglyceride [IDA]
- signal transduction [TAS]
- smooth muscle adaptation [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ZNF675
TBZF, TIZ
zinc finger protein 675
GO Process (11)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [IDA]
- bone resorption [TAS]
- cytokine-mediated signaling pathway [IDA]
- negative regulation of JNK cascade [IDA]
- negative regulation of JUN kinase activity [IDA]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of interleukin-1-mediated signaling pathway [IDA]
- negative regulation of osteoclast differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription regulatory region DNA binding [IDA]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6.
A variety of surface receptors eliciting diverse cellular responses have been shown to recruit tumor necrosis factor receptor-associated factor (TRAF) adaptor molecules. However, a few TRAF-interacting intracellular proteins that serve as downstream targets or regulators of TRAF function have been identified. In search of new intracellular molecules that bind TRAF6, we carried out a yeast two-hybrid cDNA library screening with ... [more]
J. Biol. Chem. Mar. 08, 2002; 277(10);8346-53 [Pubmed: 11751921]
Throughput
- Low Throughput
Curated By
- BioGRID