BAIT
SOX15
SOX20, SOX26, SOX27
SRY (sex determining region Y)-box 15
GO Process (12)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- cell differentiation [ISS]
- chromatin organization [NAS]
- male gonad development [TAS]
- myoblast development [ISS]
- negative regulation of striated muscle tissue development [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of G0 to G1 transition [ISS]
- positive regulation of myoblast proliferation [ISS]
- positive regulation of satellite cell activation involved in skeletal muscle regeneration [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of transcription, DNA-templated [NAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
PPP3R1
CALNB1, CNB, CNB1
protein phosphatase 3, regulatory subunit B, alpha
GO Process (9)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- apoptotic process [TAS]
- calcineurin-NFAT signaling cascade [IDA]
- dephosphorylation [NAS]
- innate immune response [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- positive regulation of NFAT protein import into nucleus [IDA]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.930399701 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT HCT116 cells CompPASS score = 0.930399701, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID