BAIT
SRR
ILV1, ISO1
serine racemase
GO Process (7)
GO Function (10)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function- ATP binding [IDA, ISS]
- L-serine ammonia-lyase activity [IDA]
- PDZ domain binding [IPI]
- calcium ion binding [ISS]
- glycine binding [ISS]
- magnesium ion binding [IDA]
- protein homodimerization activity [IDA, IPI]
- pyridoxal phosphate binding [IDA, ISS]
- serine racemase activity [IDA]
- threonine racemase activity [ISS]
- ATP binding [IDA, ISS]
- L-serine ammonia-lyase activity [IDA]
- PDZ domain binding [IPI]
- calcium ion binding [ISS]
- glycine binding [ISS]
- magnesium ion binding [IDA]
- protein homodimerization activity [IDA, IPI]
- pyridoxal phosphate binding [IDA, ISS]
- serine racemase activity [IDA]
- threonine racemase activity [ISS]
Gene Ontology Cellular Component
Homo sapiens
PREY
SRR
ILV1, ISO1
serine racemase
GO Process (7)
GO Function (10)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function- ATP binding [IDA, ISS]
- L-serine ammonia-lyase activity [IDA]
- PDZ domain binding [IPI]
- calcium ion binding [ISS]
- glycine binding [ISS]
- magnesium ion binding [IDA]
- protein homodimerization activity [IDA, IPI]
- pyridoxal phosphate binding [IDA, ISS]
- serine racemase activity [IDA]
- threonine racemase activity [ISS]
- ATP binding [IDA, ISS]
- L-serine ammonia-lyase activity [IDA]
- PDZ domain binding [IPI]
- calcium ion binding [ISS]
- glycine binding [ISS]
- magnesium ion binding [IDA]
- protein homodimerization activity [IDA, IPI]
- pyridoxal phosphate binding [IDA, ISS]
- serine racemase activity [IDA]
- threonine racemase activity [ISS]
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Direct calcium binding results in activation of brain serine racemase.
Serine racemase (SR) is a brain enzyme present in glial cells, where it isomerizes L-serine into D-serine that, in turn, diffuses and coactivates the N-methyl-D-aspartate receptor through the binding to the so-called "glycine site." We have developed a method for the slow expression of SR in a eukaryotic vector that permits the correct insertion of the prosthetic group into the ... [more]
J. Biol. Chem. Aug. 02, 2002; 277(31);27782-92 [Pubmed: 12021263]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SRR SRR | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 2737938 |
Curated By
- BioGRID