PTPRN
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SPTBN4
Gene Ontology Biological Process
- adult walking behavior [ISS]
- axon guidance [TAS]
- axonogenesis [ISS]
- cardiac conduction [ISS]
- central nervous system projection neuron axonogenesis [ISS]
- clustering of voltage-gated sodium channels [ISS]
- cytoskeletal anchoring at plasma membrane [TAS]
- establishment of protein localization to plasma membrane [ISS]
- negative regulation of heart rate [ISS]
- regulation of peptidyl-serine phosphorylation [ISS]
- regulation of sodium ion transport [ISS]
- sensory perception of sound [ISS]
- transmission of nerve impulse [ISS]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- PML body [IDA, ISS]
- adherens junction [ISS]
- axon hillock [ISS]
- axon initial segment [ISS]
- cell body fiber [ISS]
- cytoplasm [IDA, ISS]
- cytosol [TAS]
- extracellular vesicular exosome [IDA]
- membrane [IDA]
- neuronal cell body [ISS]
- node of Ranvier [ISS]
- nuclear matrix [IDA, ISS]
- plasma membrane [ISS]
- spectrin [IDA, ISS]
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system.
We report the identification of betaIV spectrin, a novel spectrin isolated as an interactor of the receptor tyrosine phosphatase-like protein ICA512. The betaIV spectrin gene is located on human and mouse chromosomes 19q13.13 and 7b2, respectively. Alternative splicing of betaIV spectrin generates at least four distinct isoforms, numbered betaIVSigma1-betaIVSigma4 spectrin. The longest isoform (betaIVSigma1 spectrin) includes an actin-binding domain, followed ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTPRN SPTBN4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID