BAIT
UBXN6
UBXD1, UBXDC2
UBX domain protein 6
GO Process (0)
GO Function (1)
GO Component (3)
Gene Ontology Molecular Function
Homo sapiens
PREY
SETX
ALS4, AOA2, SCAR1, bA479K20.2, RP11-203M2.2
senataxin
GO Process (19)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- DNA duplex unwinding [TAS]
- MAPK cascade [IDA]
- RNA processing [TAS]
- cellular response to DNA damage stimulus [IDA]
- cellular response to fibroblast growth factor stimulus [IDA]
- cellular response to hydrogen peroxide [IDA]
- cellular response to oxidative stress [IDA]
- cellular response to retinoic acid [IDA]
- double-strand break repair [IDA]
- fibroblast growth factor receptor signaling pathway [IDA]
- mRNA splice site selection [IMP]
- negative regulation of apoptotic process [IDA]
- positive regulation of DNA-templated transcription, initiation [IMP]
- positive regulation of DNA-templated transcription, termination [IMP]
- positive regulation of RNA splicing [IMP]
- positive regulation of neuron projection development [IDA]
- positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein kinase B signaling [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.998100147 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT HCT116 cells CompPASS score = 0.998100147, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID