Publication

Disulfide-cross-linked tau and MAP2 homodimers readily promote microtubule assembly.

Di Noto L, DeTure MA, Purich DL

The neuronal proteins Tau and MAP2 use homologous C-terminal MT-binding regions (MTBRs) to interact with microtubules, F-actin, and intermediate filaments. Although Tau-MTBR is the principal component of pronase-treated Alzheimer paired helical filaments, both Tau and MAP2 form filaments in vitro from disulfide-linked homodimers. That the critical thiol lies within a domain needed for MT binding raised the question: Does disulfide ... [more]

Throughput

• Low Throughput

Curated By

• BioGRID