PRKCI
Gene Ontology Biological Process
- Golgi vesicle budding [ISO]
- actin filament organization [IMP]
- cell migration [ISO]
- cell-cell junction organization [ISO]
- cellular protein localization [ISO]
- cellular response to insulin stimulus [IMP, ISO]
- establishment of apical/basal cell polarity [IMP]
- eye photoreceptor cell development [IMP]
- negative regulation of glial cell apoptotic process [ISO]
- negative regulation of neuron apoptotic process [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of endothelial cell apoptotic process [ISO]
- positive regulation of establishment of protein localization to plasma membrane [IMP]
- positive regulation of glial cell proliferation [ISO]
- positive regulation of glucose import [IMP]
- positive regulation of neuron projection development [ISO]
- protein phosphorylation [IDA, ISO]
- response to interleukin-1 [ISO]
- response to peptide hormone [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [ISO]
- Schmidt-Lanterman incisure [IDA]
- apical part of cell [IDA]
- apical plasma membrane [IDA]
- cell leading edge [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- intercellular bridge [ISO]
- microtubule cytoskeleton [ISO]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- tight junction [ISO]
FRS2
Gene Ontology Biological Process
- activation of MAPK activity [IMP]
- anterior/posterior axis specification, embryo [IMP]
- fibroblast growth factor receptor signaling pathway [IGI, IMP, ISO]
- forebrain development [IMP]
- gastrulation with mouth forming second [IMP]
- lens development in camera-type eye [IMP]
- lens fiber cell development [IGI, IMP]
- neuroblast proliferation [IGI, IMP]
- optic placode formation involved in camera-type eye formation [IMP]
- organ induction [IMP]
- positive regulation of signal transduction [IDA]
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [IMP]
- regulation of ERK1 and ERK2 cascade [IMP]
- regulation of apoptotic process [IMP]
- regulation of epithelial cell proliferation [IMP]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA]
- ventricular septum development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling.
FRS2 is a docker protein that recruits signaling proteins to the plasma membrane in fibroblast growth factor signal transduction. We report here that FRS2 was associated with PKC lambda when Swiss 3T3 cells were stimulated with basic fibroblast growth factor. PKC zeta, the other member of the atypical PKC subfamily, could also bind FRS2. The association between FRS2 and PKC ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID