NRXN1
Gene Ontology Biological Process
- N-methyl-D-aspartate receptor clustering [ISS]
- adult behavior [ISO, ISS]
- angiogenesis [ISS]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- cerebellar granule cell differentiation [ISS]
- establishment of protein localization [ISS]
- gamma-aminobutyric acid receptor clustering [ISS]
- gephyrin clustering [ISO, ISS]
- guanylate kinase-associated protein clustering [ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- learning [ISO, ISS]
- negative regulation of filopodium assembly [ISS]
- neuroligin clustering [ISO, ISS]
- neuromuscular process controlling balance [ISO, ISS]
- neuron cell-cell adhesion [ISS]
- neurotransmitter secretion [ISO, ISS]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISO, ISS]
- positive regulation of synapse assembly [ISO, ISS]
- positive regulation of synapse maturation [ISO, ISS]
- positive regulation of synaptic transmission, glutamatergic [ISO, ISS]
- postsynaptic density protein 95 clustering [ISO, ISS]
- postsynaptic membrane assembly [ISO, ISS]
- prepulse inhibition [ISO, ISS]
- presynaptic membrane assembly [ISS]
- protein complex assembly involved in synapse maturation [ISS]
- protein heterotetramerization [IDA]
- protein localization to synapse [ISS]
- receptor localization to synapse [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- regulation of grooming behavior [ISO, ISS]
- regulation of insulin secretion involved in cellular response to glucose stimulus [ISO]
- social behavior [ISO]
- synapse assembly [ISO, ISS]
- synaptic transmission [ISO, ISS]
- synaptic vesicle clustering [ISS]
- vesicle docking involved in exocytosis [IMP]
- vocal learning [ISO]
- vocalization behavior [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CASK
Gene Ontology Biological Process
- calcium ion import [ISO]
- intracellular protein transport [IMP]
- negative regulation of cell-matrix adhesion [ISO]
- negative regulation of cellular response to growth factor stimulus [ISO]
- negative regulation of keratinocyte proliferation [ISO]
- negative regulation of wound healing [ISO]
- positive regulation of calcium ion import [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein complex assembly [TAS]
- regulation of nucleic acid-templated transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- basement membrane [ISO]
- basolateral plasma membrane [ISO]
- cell-cell junction [ISO]
- ciliary membrane [IDA]
- cytoplasm [IDA, ISO]
- cytosol [ISO, TAS]
- dendrite [IDA]
- focal adhesion [ISO]
- membrane [IDA, ISO]
- nuclear lamina [ISO]
- nuclear matrix [ISO]
- nucleolus [ISO]
- nucleus [IDA, ISO]
- plasma membrane [IDA]
- presynaptic membrane [IDA]
- protein complex [IDA]
- synapse [ISO]
- synaptic membrane [IDA]
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins.
Neurexins are neuronal cell surface proteins with hundreds of isoforms. In yeast two-hybrid screens for intracellular molecules interacting with different neurexins, we identified a single interacting protein called CASK. CASK is composed of an N-terminal Ca2+, calmodulin-dependent protein kinase sequence and a C-terminal region that is similar to the intercellular junction proteins dlg-A, PSD95/SAP90, SAP97, Z01, and Z02 and that ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NRXN1 CASK | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| NRXN1 CASK | Co-purification Co-purification An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps. | Low | - | BioGRID | - |
Curated By
- BioGRID