BAIT
DLG1
Dlgh1, SAP97
discs, large homolog 1 (Drosophila)
GO Process (34)
GO Function (11)
GO Component (30)
Gene Ontology Biological Process
- T cell activation [ISO]
- T cell cytokine production [ISO]
- actin filament organization [ISO, ISS]
- activation of protein kinase activity [ISO]
- amyloid precursor protein metabolic process [ISO]
- branching involved in ureteric bud morphogenesis [ISO]
- cell adhesion [IEP]
- cortical actin cytoskeleton organization [ISO, ISS]
- embryonic skeletal system morphogenesis [ISO]
- endothelial cell proliferation [ISO, ISS]
- hard palate development [ISO]
- immunological synapse formation [ISO]
- lens development in camera-type eye [ISO]
- membrane raft organization [ISO]
- negative regulation of T cell proliferation [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of mitotic cell cycle [ISO, ISS]
- negative regulation of protein kinase B signaling [ISO]
- peristalsis [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of potassium ion transport [IMP, ISO]
- protein localization [ISO]
- protein localization to plasma membrane [ISO]
- regulation of membrane potential [ISO]
- regulation of myelination [ISO]
- regulation of protein localization [IMP]
- reproductive structure development [ISO]
- single organismal cell-cell adhesion [ISO, ISS]
- smooth muscle tissue development [ISO]
- tight junction assembly [ISO]
- tissue morphogenesis [ISO]
- ureteric bud development [ISO]
Gene Ontology Molecular Function- L27 domain binding [ISO]
- PDZ domain binding [IPI]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IPI]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphatase binding [ISO, ISS]
- potassium channel regulator activity [ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
- protein complex scaffold [ISO]
- protein kinase binding [IPI, ISO, ISS]
- L27 domain binding [ISO]
- PDZ domain binding [IPI]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IPI]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphatase binding [ISO, ISS]
- potassium channel regulator activity [ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
- protein complex scaffold [ISO]
- protein kinase binding [IPI, ISO, ISS]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- MPP7-DLG1-LIN7 complex [ISO]
- T-tubule [IDA]
- basal lamina [ISO]
- basal plasma membrane [IDA]
- basolateral plasma membrane [IDA, ISO, ISS]
- cell junction [ISO]
- cell projection membrane [ISO]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- cytoplasmic side of plasma membrane [ISO]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- immunological synapse [ISO]
- lateral loop [ISO]
- lateral plasma membrane [ISO]
- membrane raft [ISO]
- microtubule [ISO]
- myelin sheath abaxonal region [ISO]
- neuromuscular junction [ISO]
- neuron projection [IDA]
- node of Ranvier [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO, TAS]
- postsynaptic membrane [TAS]
- presynaptic membrane [IDA]
- synapse [ISO]
- tight junction [ISO]
Rattus norvegicus
PREY
CASK
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
GO Process (10)
GO Function (8)
GO Component (18)
Gene Ontology Biological Process
- calcium ion import [ISO]
- intracellular protein transport [IMP]
- negative regulation of cell-matrix adhesion [ISO]
- negative regulation of cellular response to growth factor stimulus [ISO]
- negative regulation of keratinocyte proliferation [ISO]
- negative regulation of wound healing [ISO]
- positive regulation of calcium ion import [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein complex assembly [TAS]
- regulation of nucleic acid-templated transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- basement membrane [ISO]
- basolateral plasma membrane [ISO]
- cell-cell junction [ISO]
- ciliary membrane [IDA]
- cytoplasm [IDA, ISO]
- cytosol [ISO, TAS]
- dendrite [IDA]
- focal adhesion [ISO]
- membrane [IDA, ISO]
- nuclear lamina [ISO]
- nuclear matrix [ISO]
- nucleolus [ISO]
- nucleus [IDA, ISO]
- plasma membrane [IDA]
- presynaptic membrane [IDA]
- protein complex [IDA]
- synapse [ISO]
- synaptic membrane [IDA]
Rattus norvegicus
Far Western
An interaction is detected between a protein immobilized on a membrane and a purified protein probe.
Publication
Identification of multiple binding partners for the amino-terminal domain of synapse-associated protein 97.
Multiprotein complexes mediate static and dynamic functions to establish and maintain cell polarity in both epithelial cells and neurons. Membrane-associated guanylate kinase (MAGUK) proteins are thought to be scaffolding molecules in these processes and bind multiple proteins via their obligate postsynaptic density (PSD)-95/Disc Large/Zona Occludens-1, Src homology 3, and guanylate kinase-like domains. Subsets of MAGUK proteins have additional protein-protein interaction ... [more]
J. Biol. Chem. Nov. 29, 2002; 277(48);46730-5 [Pubmed: 12351654]
Throughput
- Low Throughput
Curated By
- BioGRID