BAIT
CSGALNACT1
CSGalNAcT-1, ChGn, beta4GalNAcT, UNQ656/PRO1287
chondroitin sulfate N-acetylgalactosaminyltransferase 1
GO Process (18)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- UDP-N-acetylgalactosamine metabolic process [IDA]
- UDP-glucuronate metabolic process [IDA]
- anatomical structure morphogenesis [NAS]
- carbohydrate metabolic process [TAS]
- cell proliferation [NAS]
- cell recognition [NAS]
- chondroitin sulfate biosynthetic process [IDA, TAS]
- chondroitin sulfate metabolic process [TAS]
- chondroitin sulfate proteoglycan biosynthetic process [ISS]
- chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [IDA]
- dermatan sulfate proteoglycan biosynthetic process [ISS]
- extracellular matrix organization [NAS]
- glycosaminoglycan metabolic process [TAS]
- heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [NAS]
- heparin biosynthetic process [NAS]
- nervous system development [NAS]
- proteoglycan biosynthetic process [ISS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- acetylgalactosaminyltransferase activity [IDA, ISS]
- glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [IDA]
- glucuronosyltransferase activity [IDA]
- glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [IDA]
- metal ion binding [NAS]
- peptidoglycan glycosyltransferase activity [IDA]
- acetylgalactosaminyltransferase activity [IDA, ISS]
- glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [IDA]
- glucuronosyltransferase activity [IDA]
- glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity [IDA]
- metal ion binding [NAS]
- peptidoglycan glycosyltransferase activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
ACTR6
ARP6, HSPC281, MSTP136, hARP6, hARPX, CDA12
ARP6 actin-related protein 6 homolog (yeast)
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.999994749 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT HCT116 cells CompPASS score = 0.999994749, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID