BAIT
NRXN1
Nrxn1b
neurexin 1
GO Process (40)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- N-methyl-D-aspartate receptor clustering [ISS]
- adult behavior [ISO, ISS]
- angiogenesis [ISS]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- cerebellar granule cell differentiation [ISS]
- establishment of protein localization [ISS]
- gamma-aminobutyric acid receptor clustering [ISS]
- gephyrin clustering [ISO, ISS]
- guanylate kinase-associated protein clustering [ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- learning [ISO, ISS]
- negative regulation of filopodium assembly [ISS]
- neuroligin clustering [ISO, ISS]
- neuromuscular process controlling balance [ISO, ISS]
- neuron cell-cell adhesion [ISS]
- neurotransmitter secretion [ISO, ISS]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISO, ISS]
- positive regulation of synapse assembly [ISO, ISS]
- positive regulation of synapse maturation [ISO, ISS]
- positive regulation of synaptic transmission, glutamatergic [ISO, ISS]
- postsynaptic density protein 95 clustering [ISO, ISS]
- postsynaptic membrane assembly [ISO, ISS]
- prepulse inhibition [ISO, ISS]
- presynaptic membrane assembly [ISS]
- protein complex assembly involved in synapse maturation [ISS]
- protein heterotetramerization [IDA]
- protein localization to synapse [ISS]
- receptor localization to synapse [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- regulation of grooming behavior [ISO, ISS]
- regulation of insulin secretion involved in cellular response to glucose stimulus [ISO]
- social behavior [ISO]
- synapse assembly [ISO, ISS]
- synaptic transmission [ISO, ISS]
- synaptic vesicle clustering [ISS]
- vesicle docking involved in exocytosis [IMP]
- vocal learning [ISO]
- vocalization behavior [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
APBA2
Mint2
amyloid beta (A4) precursor protein-binding, family A, member 2
GO Process (6)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mints as adaptors. Direct binding to neurexins and recruitment of munc18.
Mint1 (X11/human Lin-10) and Mint2 are neuronal adaptor proteins that bind to Munc18-1 (n/rb-sec1), a protein essential for synaptic vesicle exocytosis. Mint1 has previously been characterized in a complex with CASK, another adaptor protein that in turn interacts with neurexins. Neurexins are neuron-specific cell surface proteins that act as receptors for the excitatory neurotoxin alpha-latrotoxin. Hence, one possible function for ... [more]
J. Biol. Chem. Dec. 22, 2000; 275(51);39803-6 [Pubmed: 11036064]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NRXN1 APBA2 | Co-purification Co-purification An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps. | Low | - | BioGRID | - |
Curated By
- BioGRID