BAIT
PPARGC1A
LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
GO Process (32)
GO Function (12)
GO Component (3)
Gene Ontology Biological Process
- RNA splicing [TAS]
- androgen receptor signaling pathway [NAS]
- brown fat cell differentiation [TAS]
- cellular glucose homeostasis [NAS]
- cellular respiration [TAS]
- cellular response to oxidative stress [ISS]
- circadian regulation of gene expression [ISS]
- digestion [TAS]
- fatty acid oxidation [NAS]
- gluconeogenesis [NAS]
- mRNA processing [TAS]
- mitochondrion organization [NAS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of neuron death [IGI]
- positive regulation of ATP biosynthetic process [ISS]
- positive regulation of energy homeostasis [ISS]
- positive regulation of fatty acid oxidation [TAS]
- positive regulation of gluconeogenesis [TAS]
- positive regulation of histone acetylation [TAS]
- positive regulation of mitochondrion organization [IBA, ISS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of transcription, DNA-templated [IDA, NAS]
- protein complex assembly [TAS]
- protein stabilization [TAS]
- regulation of circadian rhythm [ISS]
- regulation of transcription, DNA-templated [IDA]
- respiratory electron transport chain [ISS]
- response to muscle activity [ISS]
- response to starvation [NAS]
- temperature homeostasis [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- DNA binding [ISS, TAS]
- RNA binding [TAS]
- RNA polymerase II transcription cofactor activity [TAS]
- androgen receptor binding [NAS]
- chromatin DNA binding [ISS]
- ligand-dependent nuclear receptor binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [TAS]
- ubiquitin protein ligase binding [IPI]
- DNA binding [ISS, TAS]
- RNA binding [TAS]
- RNA polymerase II transcription cofactor activity [TAS]
- androgen receptor binding [NAS]
- chromatin DNA binding [ISS]
- ligand-dependent nuclear receptor binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [TAS]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
NR3C1
GCCR, GCR, GCRST, GR, GRL
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
GO Process (8)
GO Function (8)
GO Component (4)
Gene Ontology Biological Process
- cellular response to steroid hormone stimulus [IDA]
- gene expression [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA]
- signal transduction [TAS]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- glucocorticoid receptor activity [TAS]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- steroid binding [IDA]
- steroid hormone binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- glucocorticoid receptor activity [TAS]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- steroid binding [IDA]
- steroid hormone binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen.
Steroid receptors mediate responses to lipophilic hormones in a tissue- and ligand-specific manner. To identify nonreceptor proteins that confer specificity or regulate steroid signaling, we screened a human cDNA library in a steroid-responsive yeast strain. One of the identified cDNAs, isolated in the screen as ligand effect modulator 6, showed no homology to yeast or Caenorhabditis elegans proteins but high ... [more]
Mol. Cell. Biol. Apr. 01, 2000; 20(7);2411-22 [Pubmed: 10713165]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NR3C1 PPARGC1A | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | Low | - | BioGRID | 658061 | |
| NR3C1 PPARGC1A | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | High | - | BioGRID | - |
Curated By
- BioGRID