ANXA2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
APOH
Gene Ontology Biological Process
- blood coagulation, intrinsic pathway [IDA]
- negative regulation of angiogenesis [IDA]
- negative regulation of blood coagulation [IDA]
- negative regulation of endothelial cell migration [IDA]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of fibrinolysis [IDA]
- negative regulation of myeloid cell apoptotic process [IDA]
- negative regulation of smooth muscle cell apoptotic process [IDA]
- plasminogen activation [IDA]
- positive regulation of blood coagulation [TAS]
- positive regulation of lipoprotein lipase activity [IDA]
- regulation of fibrinolysis [IDA]
- triglyceride metabolic process [IDA]
- triglyceride transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
High affinity binding of beta 2-glycoprotein I to human endothelial cells is mediated by annexin II.
Beta(2)-glycoprotein I (beta(2)GPI) is an abundant plasma phospholipid-binding protein and an autoantigen in the antiphospholipid antibody syndrome. Binding of beta(2)GPI to endothelial cells targets them for activation by anti-beta(2)GPI antibodies, which circulate and are associated with thrombosis in patients with the antiphospholipid antibody syndrome. However, the binding of beta(2)GPI to endothelial cells has not been characterized and is assumed to ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID