BAIT
LYN
JTK8, p53Lyn, p56Lyn
LYN proto-oncogene, Src family tyrosine kinase
GO Process (58)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- B cell homeostasis [ISS]
- Fc receptor mediated inhibitory signaling pathway [ISS]
- Fc receptor mediated stimulatory signaling pathway [IBA, ISS]
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- T cell costimulation [TAS]
- blood coagulation [TAS]
- cellular response to DNA damage stimulus [IDA]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to retinoic acid [IMP]
- central nervous system development [IBA]
- dendritic cell differentiation [IBA, ISS]
- erythrocyte differentiation [ISS]
- immune response-regulating cell surface receptor signaling pathway [ISS, TAS]
- inflammatory response [IBA]
- innate immune response [IBA, TAS]
- leukocyte migration [TAS]
- lipopolysaccharide-mediated signaling pathway [ISS]
- negative regulation of B cell proliferation [IBA]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of MAP kinase activity [ISS]
- negative regulation of cell proliferation [IMP]
- negative regulation of immune response [TAS]
- negative regulation of intracellular signal transduction [ISS]
- negative regulation of mast cell proliferation [IBA, ISS]
- negative regulation of protein phosphorylation [ISS]
- negative regulation of toll-like receptor 2 signaling pathway [ISS]
- negative regulation of toll-like receptor 4 signaling pathway [ISS]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- platelet activation [TAS]
- platelet degranulation [IBA, ISS]
- positive regulation of cell proliferation [ISS]
- positive regulation of cellular component movement [IDA]
- positive regulation of dendritic cell apoptotic process [IBA, ISS]
- positive regulation of mast cell proliferation [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of stress-activated protein kinase signaling cascade [IDA]
- positive regulation of tyrosine phosphorylation of STAT protein [ISS]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of B cell apoptotic process [IBA]
- regulation of B cell receptor signaling pathway [IBA, ISS]
- regulation of ERK1 and ERK2 cascade [ISS]
- regulation of cell adhesion mediated by integrin [IMP]
- regulation of cytokine production [ISS]
- regulation of erythrocyte differentiation [ISS]
- regulation of mast cell activation [ISS]
- regulation of mast cell degranulation [IBA, ISS]
- regulation of monocyte chemotaxis [IMP]
- regulation of platelet aggregation [IBA, ISS]
- regulation of protein phosphorylation [TAS]
- response to hormone [ISS]
- signal transduction [TAS]
- signal transduction by phosphorylation [TAS]
- tolerance induction to self antigen [IBA, ISS, TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CSF1R
C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R
colony stimulating factor 1 receptor
GO Process (31)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- cell proliferation [IMP]
- cell-cell junction maintenance [IMP]
- cellular response to cytokine stimulus [ISS]
- cellular response to macrophage colony-stimulating factor stimulus [IMP]
- cytokine-mediated signaling pathway [IMP]
- hemopoiesis [IMP]
- inflammatory response [TAS]
- macrophage differentiation [TAS]
- mammary gland duct morphogenesis [TAS]
- monocyte differentiation [TAS]
- multicellular organismal development [TAS]
- osteoclast differentiation [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol metabolic process [ISS]
- phosphatidylinositol-mediated signaling [ISS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of cell migration [ISS]
- positive regulation of cell motility [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of chemokine secretion [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of protein serine/threonine kinase activity [ISS]
- positive regulation of protein tyrosine kinase activity [IMP]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISS]
- protein autophosphorylation [IDA]
- regulation of actin cytoskeleton reorganization [ISS]
- regulation of bone resorption [ISS]
- regulation of cell shape [IMP]
- ruffle organization [ISS]
- signal transduction [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Association between Lyn protein tyrosine kinase (p53/56lyn) and the beta subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors in a GM-CSF-dependent human megakaryocytic leukemia cell line (M-07e).
The role of the lyn product (p53/p56lyn), a membrane-associated protein tyrosine kinase in the signaling pathway used by granulocyte macrophage-CSFR (GM-CSFR) was investigated by using the GM-CSF-dependent human megakaryoblastic leukemia cell line M-07e. M-07e cells express GM-CSFR and are dependent on GM-CSF for survival and proliferation in vitro. Treatment with anti-lyn Abs coimmunoprecipitated, along with lyn product, the beta subunit ... [more]
J. Immunol. Aug. 15, 1995; 155(4);2165-74 [Pubmed: 7636265]
Throughput
- Low Throughput
Curated By
- BioGRID