CD5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RASA1
Gene Ontology Biological Process
- blood vessel morphogenesis [IMP]
- embryo development [ISS]
- intracellular signal transduction [NAS]
- mitotic cytokinesis [ISS]
- negative regulation of Ras protein signal transduction [IBA]
- negative regulation of cell adhesion [IDA]
- negative regulation of cell-matrix adhesion [IDA]
- negative regulation of neuron apoptotic process [ISS]
- positive regulation of Ras GTPase activity [IBA]
- regulation of RNA metabolic process [NAS]
- regulation of actin filament polymerization [IDA]
- regulation of cell shape [NAS]
- signal transduction [IDA]
- vasculogenesis [ISS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Thymocyte activation induces the association of the proto-oncoprotein c-cbl and ras GTPase-activating protein with CD5.
Studies of knockout mice indicate that the glycoprotein CD5, which is expressed on Tcells, most thymocytes and a subset of B cells, down-regulates TCR- and B cell receptor (BCR)-mediated signaling. CD5 is associated with the TCR and BCR, and is phosphorylated on cytoplasmic tyrosine residues following antigen receptor ligation. Cross-linking of CD5 or pervanadate stimulation of thymocytes induces the association ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID