Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Interactions between pyruvate carboxylase and other mitochondrial enzymes.

Fahien LA, Davis JW, Laboy J

Although pyruvate carboxylase associated with both mitochondrial aspartate aminotransferase and malate dehydrogenase, it had a higher affinity for the amino-transferase. Furthermore, the aminotransferase enhanced dissociation of malate dehydrogenase from pyruvate carboxylase. Glutamate dehydrogenase did not associate with pyruvate carboxylase alone, but it apparently associated with the pyruvate carboxylase-aminotransferase complex, and malate dehydrogenase associated with the resulting ternary complex. Citrate synthase ... [more]

J. Biol. Chem. Aug. 25, 1993; 268(24);17935-42 [Pubmed: 8349677]

Throughput

  • Low Throughput

Curated By

  • BioGRID