BAIT
ADIPOQ
ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28
adiponectin, C1Q and collagen domain containing
GO Process (57)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- brown fat cell differentiation [ISS]
- cellular response to drug [ISS]
- cellular response to insulin stimulus [ISS]
- detection of oxidative stress [ISS]
- fatty acid beta-oxidation [ISS]
- fatty acid oxidation [ISS]
- generation of precursor metabolites and energy [TAS]
- glucose homeostasis [ISS]
- glucose metabolic process [ISS]
- low-density lipoprotein particle clearance [IDA]
- negative regulation of DNA biosynthetic process [IDA]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of MAP kinase activity [ISS]
- negative regulation of blood pressure [IDA]
- negative regulation of cell migration [ISS]
- negative regulation of fat cell differentiation [IDA]
- negative regulation of gluconeogenesis [ISS]
- negative regulation of granulocyte differentiation [IDA]
- negative regulation of heterotypic cell-cell adhesion [IDA]
- negative regulation of inflammatory response [ISS, NAS]
- negative regulation of intracellular protein transport [IDA]
- negative regulation of low-density lipoprotein particle receptor biosynthetic process [IDA]
- negative regulation of macrophage derived foam cell differentiation [IDA]
- negative regulation of macrophage differentiation [IDA]
- negative regulation of metanephric mesenchymal cell migration [ISS]
- negative regulation of phagocytosis [IDA]
- negative regulation of platelet-derived growth factor receptor signaling pathway [IDA]
- negative regulation of platelet-derived growth factor receptor-alpha signaling pathway [ISS]
- negative regulation of protein autophosphorylation [IDA]
- negative regulation of receptor binding [IDA]
- negative regulation of smooth muscle cell migration [IDA]
- negative regulation of smooth muscle cell proliferation [IDA]
- negative regulation of synaptic transmission [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of tumor necrosis factor production [IDA]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- positive regulation of cAMP-dependent protein kinase activity [IDA]
- positive regulation of cellular protein metabolic process [IDA]
- positive regulation of cholesterol efflux [IDA]
- positive regulation of fatty acid metabolic process [ISS]
- positive regulation of glucose import [ISS]
- positive regulation of glycogen (starch) synthase activity [ISS]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of metanephric glomerular visceral epithelial cell development [ISS]
- positive regulation of monocyte chemotactic protein-1 production [IDA]
- positive regulation of myeloid cell apoptotic process [IDA]
- positive regulation of protein kinase A signaling [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of renal albumin absorption [IDA]
- positive regulation of signal transduction [ISS]
- protein homooligomerization [ISS]
- protein localization to plasma membrane [IDA]
- regulation of glucose metabolic process [IDA]
- response to glucose [ISS]
- response to tumor necrosis factor [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
METRN
C16orf23, c380A1.2, RJD6
meteorin, glial cell differentiation regulator
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.914468239 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT HCT116 cells CompPASS score = 0.914468239, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID