BAIT
RGS14
regulator of G-protein signaling 14
GO Process (19)
GO Function (5)
GO Component (10)
Gene Ontology Biological Process
- cell division [IMP]
- chromosome segregation [ISS]
- intracellular signal transduction [ISS]
- learning [ISS]
- long-term memory [ISS]
- long-term synaptic potentiation [ISS]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of MAP kinase activity [ISS]
- negative regulation of synaptic plasticity [ISS]
- nucleocytoplasmic transport [ISS]
- platelet-derived growth factor receptor signaling pathway [ISS]
- positive regulation of GTPase activity [IBA, IDA, TAS]
- positive regulation of neurogenesis [ISS]
- regulation of DNA-templated transcription in response to stress [ISS]
- regulation of G-protein coupled receptor protein signaling pathway [TAS]
- response to oxidative stress [ISS]
- spindle organization [IMP]
- visual learning [ISS]
- zygote asymmetric cell division [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GNAI2
GIP, GNAI2B, H_LUCA15.1, H_LUCA16.1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GO Process (11)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- adenosine receptor signaling pathway [IBA]
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [IBA, TAS]
- blood coagulation [TAS]
- cell division [IMP]
- gamma-aminobutyric acid signaling pathway [IBA]
- negative regulation of adenylate cyclase activity [TAS]
- platelet activation [TAS]
- response to nutrient [TAS]
- signal transduction [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity.
The regulators of G-protein signaling (RGS) proteins accelerate the intrinsic guanosine triphosphatase activity of heterotrimeric G-protein alpha subunits and are thus recognized as key modulators of G-protein-coupled receptor signaling. RGS12 and RGS14 contain not only the hallmark RGS box responsible for GTPase-accelerating activity but also a single G alpha(i/o)-Loco (GoLoco) motif predicted to represent a second G alpha interaction site. ... [more]
J. Biol. Chem. Aug. 03, 2001; 276(31);29275-81 [Pubmed: 11387333]
Throughput
- Low Throughput
Curated By
- BioGRID