BAIT
HLA-G
MHC-G, DADB-15K14.8
major histocompatibility complex, class I, G
GO Process (15)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cellular defense response [TAS]
- cytokine-mediated signaling pathway [TAS]
- immune response-inhibiting cell surface receptor signaling pathway [IDA]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of T cell proliferation [IDA]
- negative regulation of dendritic cell differentiation [IDA]
- positive regulation of T cell tolerance induction [IMP]
- positive regulation of interleukin-12 production [IDA]
- positive regulation of regulatory T cell differentiation [IMP]
- regulation of immune response [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
SLC25A4
1, AAC1, ANT, ANT 1, ANT1, MTDPS12, PEO2, PEO3, T1
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
GO Process (9)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- adenine transport [TAS]
- energy reserve metabolic process [TAS]
- generation of precursor metabolites and energy [TAS]
- mitochondrial genome maintenance [TAS]
- negative regulation of necroptotic process [IMP]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
- transport [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.799025141 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT HCT116 cells CompPASS score = 0.799025141, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID