BAIT
SOX9
CMD1, CMPD1, SRA1
SRY (sex determining region Y)-box 9
GO Process (70)
GO Function (10)
GO Component (3)
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [ISS]
- Sertoli cell differentiation [ISS]
- cAMP-mediated signaling [IDA]
- cartilage condensation [ISS]
- cartilage development [ISS]
- cell fate specification [ISS]
- cellular response to epidermal growth factor stimulus [ISS]
- cellular response to heparin [ISS]
- cellular response to interleukin-1 [IEP]
- cellular response to mechanical stimulus [ISS]
- cellular response to retinoic acid [IEP]
- cellular response to transforming growth factor beta stimulus [IDA]
- chondrocyte differentiation involved in endochondral bone morphogenesis [IMP]
- chondrocyte hypertrophy [ISS]
- chromatin remodeling [IDA]
- cochlea morphogenesis [ISS]
- endocardial cushion morphogenesis [ISS]
- epidermal growth factor receptor signaling pathway [ISS]
- epithelial cell proliferation involved in prostatic bud elongation [ISS]
- epithelial to mesenchymal transition [ISS]
- hair follicle development [ISS]
- heart valve development [ISS]
- heart valve morphogenesis [ISS]
- intestinal epithelial structure maintenance [ISS]
- male germ-line sex determination [ISS]
- male gonad development [IEP, IMP]
- metanephric nephron tubule formation [ISS]
- morphogenesis of a branching epithelium [ISS]
- negative regulation of apoptotic process [IMP, ISS]
- negative regulation of biomineral tissue development [ISS]
- negative regulation of canonical Wnt signaling pathway [ISS]
- negative regulation of chondrocyte differentiation [ISS]
- negative regulation of epithelial cell proliferation [ISS]
- negative regulation of immune system process [ISS]
- negative regulation of myoblast differentiation [ISS]
- negative regulation of ossification [ISS]
- negative regulation of photoreceptor cell differentiation [ISS]
- negative regulation of transcription, DNA-templated [IMP]
- nucleosome assembly [IDA]
- otic vesicle formation [ISS]
- positive regulation of branching involved in ureteric bud morphogenesis [ISS]
- positive regulation of cartilage development [IDA]
- positive regulation of cell proliferation [IMP]
- positive regulation of chondrocyte differentiation [IDA, IMP]
- positive regulation of epithelial cell differentiation [ISS]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of epithelial cell proliferation [IEP, ISS]
- positive regulation of kidney development [ISS]
- positive regulation of male gonad development [IDA]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of mesenchymal stem cell differentiation [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of protein phosphorylation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- prostate gland development [IEP]
- protein complex assembly [IDA]
- regulation of apoptotic process [ISS]
- regulation of cell cycle process [IMP]
- regulation of cell proliferation [ISS]
- regulation of cell proliferation involved in tissue homeostasis [ISS]
- renal vesicle induction [ISS]
- retina development in camera-type eye [ISS]
- retinal rod cell differentiation [ISS]
- signal transduction [ISS]
- skeletal system development [IMP]
- somatic stem cell maintenance [ISS]
- spermatogenesis [ISS]
- tissue homeostasis [ISS]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- chromatin binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- enhancer binding [IDA]
- enhancer sequence-specific DNA binding [ISS]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IPI]
- protein kinase activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- chromatin binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- enhancer binding [IDA]
- enhancer sequence-specific DNA binding [ISS]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IPI]
- protein kinase activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
Gene Ontology Cellular Component
Homo sapiens
PREY
HSPA1A
HEL-S-103, HSP70-1, HSP70-1A, HSP70I, HSP72, HSPA1, DAQB-147D11.1
heat shock 70kDa protein 1A
GO Process (20)
GO Function (13)
GO Component (17)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- RNA metabolic process [TAS]
- cellular heat acclimation [IMP]
- cellular response to heat [IDA]
- cellular response to oxidative stress [TAS]
- gene expression [TAS]
- mRNA catabolic process [IDA]
- mRNA metabolic process [TAS]
- negative regulation of apoptotic process [IMP, TAS]
- negative regulation of cell death [IDA, IMP]
- negative regulation of cell growth [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- negative regulation of inclusion body assembly [IDA]
- negative regulation of protein ubiquitination [IDA]
- positive regulation of erythrocyte differentiation [IMP]
- protein refolding [IDA]
- protein stabilization [TAS]
- regulation of cell death [IMP]
- response to unfolded protein [IDA]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase activity [IDA]
- ATPase activity, coupled [IDA]
- G-protein coupled receptor binding [IPI]
- double-stranded RNA binding [IDA]
- enzyme binding [IPI]
- heat shock protein binding [IPI]
- poly(A) RNA binding [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein binding involved in protein folding [IDA]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [IDA, NAS, TAS]
- ATP binding [IDA]
- ATPase activity [IDA]
- ATPase activity, coupled [IDA]
- G-protein coupled receptor binding [IPI]
- double-stranded RNA binding [IDA]
- enzyme binding [IPI]
- heat shock protein binding [IPI]
- poly(A) RNA binding [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein binding involved in protein folding [IDA]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [IDA, NAS, TAS]
Gene Ontology Cellular Component
- COP9 signalosome [IDA]
- aggresome [IDA]
- blood microparticle [IDA]
- centriole [IDA]
- cytoplasm [IDA, TAS]
- cytosol [IDA, TAS]
- endoplasmic reticulum [TAS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- inclusion body [IDA]
- mitochondrion [TAS]
- nuclear speck [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- ribonucleoprotein complex [IDA]
- ubiquitin ligase complex [IDA]
- vesicle [IDA]
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Identification of an interaction between SOX9 and HSP70.
The campomelic dysplasia/autosomal sex reversal protein SOX9 is an important developmental transcription factor, required for correct bone and testis formation. Through in vitro and in vivo studies we have identified the heat shock protein HSP70 as an interacting partner for SOX9 in chondrocyte and testicular cell lines. HSP70 forms a ternary complex with DNA-bound SOX9. The interaction between HSP70 and ... [more]
FEBS Lett. May. 11, 2001; 496(2);75-80 [Pubmed: 11356186]
Throughput
- Low Throughput
Curated By
- BioGRID