VCAN
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- cell recognition [TAS]
- central nervous system development [IBA]
- chondroitin sulfate biosynthetic process [TAS]
- chondroitin sulfate catabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- dermatan sulfate biosynthetic process [TAS]
- extracellular matrix organization [TAS]
- glial cell migration [IDA]
- glycosaminoglycan metabolic process [TAS]
- multicellular organismal development [TAS]
- osteoblast differentiation [IDA]
- skeletal system development [IBA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CXCL12
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- blood circulation [TAS]
- cell adhesion [TAS]
- cell chemotaxis [IDA]
- cellular calcium ion homeostasis [TAS]
- chemokine-mediated signaling pathway [IDA]
- chemotaxis [TAS]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- negative regulation of leukocyte apoptotic process [IDA]
- negative regulation of leukocyte tethering or rolling [IDA]
- positive regulation of T cell migration [IDA]
- positive regulation of calcium ion import [TAS]
- positive regulation of cell adhesion [IDA]
- positive regulation of monocyte chemotaxis [IDA]
- regulation of actin polymerization or depolymerization [TAS]
- response to virus [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Versican interacts with chemokines and modulates cellular responses.
We previously reported that versican, a large chondroitin sulfate proteoglycan, isolated from a renal adenocarcinoma cell line, ACHN, binds L-selectin. Here we report that versican also binds certain chemokines and regulates chemokine function. This binding was strongly inhibited by the chondroitinase digestion of versican or by the addition of soluble chondroitin sulfate (CS) B, CS E, or heparan sulfate. Furthermore, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID