VCAN
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- cell recognition [TAS]
- central nervous system development [IBA]
- chondroitin sulfate biosynthetic process [TAS]
- chondroitin sulfate catabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- dermatan sulfate biosynthetic process [TAS]
- extracellular matrix organization [TAS]
- glial cell migration [IDA]
- glycosaminoglycan metabolic process [TAS]
- multicellular organismal development [TAS]
- osteoblast differentiation [IDA]
- skeletal system development [IBA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CCL2
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [TAS]
- JAK-STAT cascade [TAS]
- MAPK cascade [IMP]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- angiogenesis [TAS]
- astrocyte cell migration [IDA]
- cell adhesion [TAS]
- cell surface receptor signaling pathway [TAS]
- cellular homeostasis [TAS]
- cellular protein metabolic process [TAS]
- cellular response to fibroblast growth factor stimulus [IEP]
- cellular response to interferon-gamma [IEP, ISS]
- cellular response to interleukin-1 [IEP, ISS]
- cellular response to lipopolysaccharide [ISS]
- cellular response to organic cyclic compound [IDA]
- cellular response to tumor necrosis factor [IEP, ISS]
- chemotaxis [TAS]
- cytokine-mediated signaling pathway [IDA]
- cytoskeleton organization [IDA]
- endoplasmic reticulum unfolded protein response [TAS]
- helper T cell extravasation [ISS]
- humoral immune response [TAS]
- inflammatory response [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- macrophage chemotaxis [IDA]
- monocyte chemotaxis [IDA]
- negative regulation of glial cell apoptotic process [IDA]
- negative regulation of natural killer cell chemotaxis [IDA]
- negative regulation of neuron apoptotic process [IDA]
- organ morphogenesis [TAS]
- positive regulation of T cell activation [ISS]
- positive regulation of apoptotic cell clearance [ISS]
- positive regulation of calcium ion import [IDA]
- positive regulation of nitric-oxide synthase biosynthetic process [ISS]
- protein kinase B signaling [IMP]
- protein phosphorylation [TAS]
- regulation of cell shape [IDA]
- response to bacterium [IEP]
- signal transduction [NAS]
- viral genome replication [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Versican interacts with chemokines and modulates cellular responses.
We previously reported that versican, a large chondroitin sulfate proteoglycan, isolated from a renal adenocarcinoma cell line, ACHN, binds L-selectin. Here we report that versican also binds certain chemokines and regulates chemokine function. This binding was strongly inhibited by the chondroitinase digestion of versican or by the addition of soluble chondroitin sulfate (CS) B, CS E, or heparan sulfate. Furthermore, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID