VCAN
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- cell recognition [TAS]
- central nervous system development [IBA]
- chondroitin sulfate biosynthetic process [TAS]
- chondroitin sulfate catabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- dermatan sulfate biosynthetic process [TAS]
- extracellular matrix organization [TAS]
- glial cell migration [IDA]
- glycosaminoglycan metabolic process [TAS]
- multicellular organismal development [TAS]
- osteoblast differentiation [IDA]
- skeletal system development [IBA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CCL5
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- MAPK cascade [IMP]
- activation of phospholipase D activity [IDA]
- calcium ion transport [IDA]
- cell-cell signaling [IDA]
- cellular calcium ion homeostasis [IDA]
- cellular protein complex assembly [IDA]
- cellular response to fibroblast growth factor stimulus [IEP]
- cellular response to interferon-gamma [IEP]
- cellular response to interleukin-1 [IEP]
- cellular response to organic cyclic compound [IDA]
- cellular response to tumor necrosis factor [IEP]
- chemokine-mediated signaling pathway [IDA, TAS]
- chemotaxis [NAS]
- dendritic cell chemotaxis [TAS]
- eosinophil chemotaxis [IDA]
- exocytosis [IDA]
- inflammatory response [IDA]
- leukocyte cell-cell adhesion [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- macrophage chemotaxis [TAS]
- monocyte chemotaxis [IC]
- negative regulation by host of viral transcription [IDA]
- negative regulation of G-protein coupled receptor protein signaling pathway [IDA]
- negative regulation of T cell apoptotic process [IDA]
- negative regulation of chemokine-mediated signaling pathway [IDA]
- negative regulation of viral genome replication [IDA]
- neutrophil activation [IDA]
- positive chemotaxis [IDA]
- positive regulation of JAK-STAT cascade [TAS]
- positive regulation of T cell apoptotic process [IDA]
- positive regulation of T cell chemotaxis [IDA]
- positive regulation of T cell migration [IDA]
- positive regulation of T cell proliferation [IDA]
- positive regulation of activation of JAK2 kinase activity [TAS]
- positive regulation of calcium ion transport [IDA]
- positive regulation of cell adhesion [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell-cell adhesion mediated by integrin [IDA]
- positive regulation of cellular biosynthetic process [IDA]
- positive regulation of homotypic cell-cell adhesion [IDA]
- positive regulation of innate immune response [TAS]
- positive regulation of macrophage chemotaxis [IDA]
- positive regulation of monocyte chemotaxis [IDA]
- positive regulation of natural killer cell chemotaxis [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of phosphorylation [IDA]
- positive regulation of protein tyrosine kinase activity [IDA]
- positive regulation of smooth muscle cell migration [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of translational initiation [NAS]
- positive regulation of tyrosine phosphorylation of STAT protein [IDA]
- positive regulation of viral genome replication [TAS]
- protein kinase B signaling [IMP]
- protein phosphorylation [IDA]
- protein tetramerization [IDA]
- regulation of T cell activation [IDA]
- regulation of chronic inflammatory response [TAS]
- regulation of insulin secretion [IDA]
- regulation of neuron death [IDA]
- response to toxic substance [IDA]
- response to virus [TAS]
Gene Ontology Molecular Function- CCR1 chemokine receptor binding [IDA, IPI, TAS]
- CCR4 chemokine receptor binding [TAS]
- CCR5 chemokine receptor binding [IPI]
- chemoattractant activity [IDA]
- chemokine activity [IDA, NAS]
- chemokine receptor antagonist activity [IDA]
- chemokine receptor binding [IPI]
- phosphatidylinositol phospholipase C activity [IDA]
- phospholipase activator activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activity [IDA]
- protein self-association [IDA]
- receptor signaling protein tyrosine kinase activator activity [IDA]
- CCR1 chemokine receptor binding [IDA, IPI, TAS]
- CCR4 chemokine receptor binding [TAS]
- CCR5 chemokine receptor binding [IPI]
- chemoattractant activity [IDA]
- chemokine activity [IDA, NAS]
- chemokine receptor antagonist activity [IDA]
- chemokine receptor binding [IPI]
- phosphatidylinositol phospholipase C activity [IDA]
- phospholipase activator activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activity [IDA]
- protein self-association [IDA]
- receptor signaling protein tyrosine kinase activator activity [IDA]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Versican interacts with chemokines and modulates cellular responses.
We previously reported that versican, a large chondroitin sulfate proteoglycan, isolated from a renal adenocarcinoma cell line, ACHN, binds L-selectin. Here we report that versican also binds certain chemokines and regulates chemokine function. This binding was strongly inhibited by the chondroitinase digestion of versican or by the addition of soluble chondroitin sulfate (CS) B, CS E, or heparan sulfate. Furthermore, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID