CRLF1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CLCF1
Gene Ontology Biological Process
- B cell differentiation [ISS]
- JAK-STAT cascade [ISS]
- cell surface receptor signaling pathway [ISS]
- cytokine-mediated signaling pathway [NAS]
- negative regulation of neuron apoptotic process [IDA]
- positive regulation of B cell proliferation [ISS]
- positive regulation of astrocyte differentiation [ISS]
- positive regulation of cell proliferation [IDA]
- positive regulation of immunoglobulin production [ISS]
- positive regulation of isotype switching to IgE isotypes [ISS]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IDA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex.
Ciliary neurotrophic factor (CNTF) is a cytokine supporting the differentiation and survival of various cell types in the peripheral and central nervous systems. Its receptor complex consists of a non-signaling alpha chain, CNTFR, and two signaling beta chains, gp130 and the leukemia inhibitory factor receptor (LIFR). Striking phenotypic differences between CNTF- and CNTFR-deficient mice suggest that CNTFR serves as a ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CLCF1 CRLF1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9838 | BioGRID | 3273885 |
Curated By
- BioGRID