BAIT
ATN1
B37, D12S755E, DRPLA, HRS, NOD
atrophin 1
GO Process (3)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MAGI2
ACVRIP1, AIP-1, AIP1, ARIP1, MAGI-2, SSCAM
membrane associated guanylate kinase, WW and PDZ domain containing 2
GO Process (16)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- SMAD protein signal transduction [ISS]
- cellular response to nerve growth factor stimulus [ISS]
- cytoplasmic transport [ISS]
- glomerular visceral epithelial cell development [ISS]
- mitotic cell cycle arrest [ISS]
- negative regulation of activin receptor signaling pathway [ISS]
- negative regulation of cell migration [ISS]
- negative regulation of cell proliferation [ISS]
- negative regulation of protein kinase B signaling [IDA]
- nerve growth factor signaling pathway [ISS]
- planar cell polarity pathway involved in axis elongation [NAS]
- positive regulation of neuron projection development [ISS]
- positive regulation of phosphoprotein phosphatase activity [IDA]
- positive regulation of receptor internalization [IDA]
- protein heterooligomerization [ISS]
- receptor clustering [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy (DRPLA). The normal function of atrophin-1 is unknown. We have identified five atrophin-1 interacting proteins (AIPs) which bind to atrophin-1 in the vicinity of the polyglutamine tract using the yeast two-hybrid system. Four of the interactions were confirmed using in vitro binding assays. All five ... [more]
Mol. Cell. Neurosci. Jun. 01, 1998; 11(3);149-60 [Pubmed: 9647693]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAGI2 ATN1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID