DMTN
Gene Ontology Biological Process
- actin cytoskeleton organization [ISS]
- actin filament bundle assembly [IDA, TAS]
- actin filament reorganization [ISS]
- calcium-mediated signaling using extracellular calcium source [ISS]
- calcium-mediated signaling using intracellular calcium source [ISS]
- cellular response to cAMP [IDA]
- cellular response to calcium ion [ISS]
- cytoskeleton organization [TAS]
- erythrocyte development [ISS]
- negative regulation of cell-substrate adhesion [ISS]
- negative regulation of focal adhesion assembly [ISS]
- negative regulation of peptidyl-serine phosphorylation [ISS]
- negative regulation of peptidyl-threonine phosphorylation [ISS]
- negative regulation of peptidyl-tyrosine phosphorylation [ISS]
- negative regulation of protein targeting to membrane [ISS]
- negative regulation of substrate adhesion-dependent cell spreading [ISS]
- positive regulation of blood coagulation [ISS]
- positive regulation of fibroblast migration [ISS]
- positive regulation of integrin-mediated signaling pathway [ISS]
- positive regulation of platelet aggregation [ISS]
- positive regulation of substrate adhesion-dependent cell spreading [ISS]
- positive regulation of wound healing [ISS]
- protein complex assembly [IDA, ISS]
- protein secretion by platelet [ISS]
- regulation of actin cytoskeleton organization [IDA]
- regulation of cell shape [IMP]
- regulation of filopodium assembly [IMP]
- regulation of lamellipodium assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
YWHAE
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- apoptotic process [TAS]
- apoptotic signaling pathway [TAS]
- hippo signaling [TAS]
- intracellular signal transduction [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- membrane organization [TAS]
- membrane repolarization during cardiac muscle cell action potential [IC]
- mitotic cell cycle [TAS]
- negative regulation of peptidyl-serine dephosphorylation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- regulation of heart rate by cardiac conduction [IC]
- regulation of heart rate by hormone [NAS]
- regulation of membrane repolarization [IDA]
- regulation of potassium ion transmembrane transporter activity [IDA]
- substantia nigra development [IEP]
Gene Ontology Molecular Function- MHC class II protein complex binding [IDA]
- enzyme binding [IPI]
- histone deacetylase binding [IPI]
- ion channel binding [IPI]
- phosphoprotein binding [IPI]
- phosphoserine binding [IPI]
- poly(A) RNA binding [IDA]
- potassium channel regulator activity [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- MHC class II protein complex binding [IDA]
- enzyme binding [IPI]
- histone deacetylase binding [IPI]
- ion channel binding [IPI]
- phosphoprotein binding [IPI]
- phosphoserine binding [IPI]
- poly(A) RNA binding [IDA]
- potassium channel regulator activity [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.985131035 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT HCT116 cells CompPASS score = 0.985131035, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DMTN YWHAE | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8063 | BioGRID | 1192985 | |
| DMTN YWHAE | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.7879 | BioGRID | 2269733 | |
| YWHAE DMTN | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | 3536127 |
Curated By
- BioGRID