BAIT

SMN2

BCD541, C-BCD541, GEMIN1, SMNC, TDRD16B
survival of motor neuron 2, centromeric
Homo sapiens
PREY

SNRPD1

HsT2456, SMD1, SNRPD, Sm-D1
small nuclear ribonucleoprotein D1 polypeptide 16kDa
Homo sapiens

Reconstituted Complex

An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.

Publication

Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy.

Buehler D, Raker V, Luehrmann R, Fischer U

Spinal muscular atrophy (SMA) is a neurodegenerative disease of spinal motor neurons caused by reduced levels of functional survival of motor neurons (SMN) protein. SMN is part of a macromolecular complex that contains the SMN-interacting protein 1 (SIP1) and spliceosomal Sm proteins. Although it is clear that SIP1 as a component of this complex is essential for spliceosomal uridine-rich small ... [more]

Hum. Mol. Genet. Dec. 01, 1999; 8(13);2351-7 [Pubmed: 10556282]

Throughput

  • Low Throughput

Curated By

  • BioGRID