BAIT
TRDN
CPVT5, TDN, TRISK, RP11-167I10.1
triadin
GO Process (15)
GO Function (4)
GO Component (11)
Gene Ontology Biological Process
- cellular calcium ion homeostasis [ISS]
- cytoplasmic microtubule organization [ISS]
- endoplasmic reticulum membrane organization [ISS]
- heart contraction [IMP]
- ion transmembrane transport [TAS]
- muscle contraction [TAS]
- negative regulation of ryanodine-sensitive calcium-release channel activity [TAS]
- positive regulation of cell communication by electrical coupling involved in cardiac conduction [ISS]
- positive regulation of ryanodine-sensitive calcium-release channel activity [ISS, TAS]
- regulation of cardiac muscle cell membrane potential [ISS]
- regulation of cell communication by electrical coupling [TAS]
- regulation of release of sequestered calcium ion into cytosol [TAS]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISS]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- calcium channel complex [ISS]
- cytoplasm [IDA]
- endoplasmic reticulum [ISS]
- integral component of membrane [TAS]
- junctional membrane complex [ISS]
- junctional sarcoplasmic reticulum membrane [ISS, TAS]
- plasma membrane [IDA]
- sarcoplasmic reticulum [ISS]
- sarcoplasmic reticulum lumen [TAS]
- sarcoplasmic reticulum membrane [TAS]
- voltage-gated calcium channel complex [ISS]
Homo sapiens
PREY
RPS4X
CCG2, DXS306, RPS4, S4, SCAR, SCR10
ribosomal protein S4, X-linked
GO Process (16)
GO Function (2)
GO Component (10)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- multicellular organismal development [IMP]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- positive regulation of cell proliferation [IMP]
- positive regulation of translation [IMP]
- translation [IC, IMP, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.780252939 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT HCT116 cells CompPASS score = 0.780252939, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID