KCNE1
Gene Ontology Biological Process
- cardiac muscle cell action potential involved in contraction [IMP]
- cellular response to cAMP [IDA]
- membrane repolarization [IDA]
- membrane repolarization during action potential [IDA]
- membrane repolarization during cardiac muscle cell action potential [IDA, IMP]
- positive regulation of potassium ion transmembrane transport [IDA]
- potassium ion export [IDA]
- potassium ion transmembrane transport [IDA]
- protein N-linked glycosylation [IDA]
- protein O-linked glycosylation [IDA]
- regulation of delayed rectifier potassium channel activity [IDA]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of potassium ion transmembrane transport [IDA]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- sensory perception of sound [TAS]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function- delayed rectifier potassium channel activity [IDA]
- potassium channel regulator activity [IDA]
- protein binding [IPI]
- telethonin binding [IPI]
- voltage-gated potassium channel activity [IDA]
- voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [IDA]
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [IMP]
- delayed rectifier potassium channel activity [IDA]
- potassium channel regulator activity [IDA]
- protein binding [IPI]
- telethonin binding [IPI]
- voltage-gated potassium channel activity [IDA]
- voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [IDA]
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [IMP]
Gene Ontology Cellular Component
KCNH2
Gene Ontology Biological Process
- cardiac muscle contraction [IMP]
- cellular response to drug [IDA]
- membrane depolarization during action potential [IDA]
- membrane repolarization during action potential [IDA]
- membrane repolarization during cardiac muscle cell action potential [IMP]
- negative regulation of potassium ion export [IDA]
- negative regulation of potassium ion transmembrane transport [IDA]
- positive regulation of potassium ion transmembrane transport [IDA]
- potassium ion export [IDA]
- potassium ion homeostasis [IDA]
- potassium ion transmembrane transport [IDA]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of heart rate by hormone [TAS]
- regulation of membrane potential [IDA]
- regulation of membrane repolarization [IDA]
- regulation of potassium ion transmembrane transport [IDA]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- synaptic transmission [TAS]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function- delayed rectifier potassium channel activity [IDA]
- identical protein binding [IPI]
- inward rectifier potassium channel activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
- voltage-gated potassium channel activity [IDA]
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [IMP]
- delayed rectifier potassium channel activity [IDA]
- identical protein binding [IPI]
- inward rectifier potassium channel activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
- voltage-gated potassium channel activity [IDA]
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [IMP]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A minK-HERG complex regulates the cardiac potassium current I(Kr).
MinK is a widely expressed protein of relative molecular mass approximately 15K that forms potassium channels by aggregation with other membrane proteins. MinK governs ion channel activation, regulation by second messengers, and the function and structure of the ion conduction pathway. Association of minK with a channel protein known as KvLQT1 produces a voltage-gated outward K+ current (I[sK]) resembling the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID