FGF7
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- actin cytoskeleton reorganization [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- epidermis development [TAS]
- fibroblast growth factor receptor signaling pathway [IGI, TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- mesenchymal cell proliferation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive chemotaxis [IDA]
- positive regulation of cell proliferation [IGI]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of epithelial cell proliferation involved in lung morphogenesis [IDA]
- positive regulation of keratinocyte migration [IDA]
- positive regulation of keratinocyte proliferation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- protein localization to cell surface [IDA]
- response to wounding [TAS]
- secretion by lung epithelial cell involved in lung growth [IDA]
- signal transduction [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HSPG2
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- glycosaminoglycan biosynthetic process [TAS]
- glycosaminoglycan catabolic process [TAS]
- glycosaminoglycan metabolic process [TAS]
- lipoprotein metabolic process [TAS]
- phototransduction, visible light [TAS]
- retinoid metabolic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7.
Perlecan is a multifaceted heparan sulfate proteoglycan that is expressed not only as an intrinsic constituent of basement membranes but also as a cell-surface and pericellular proteoglycan. Perlecan functions as a ligand reservoir for various growth factors that become stabilized against misfolding or proteolysis and acts as a co-receptor for basic fibroblast growth factor by augmenting high affinity binding and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FGF7 HSPG2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| FGF7 HSPG2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID