CD1D
Gene Ontology Biological Process
- T cell selection [TAS]
- antigen processing and presentation, endogenous lipid antigen via MHC class Ib [IDA]
- antigen processing and presentation, exogenous lipid antigen via MHC class Ib [IBA]
- detection of bacterium [TAS]
- heterotypic cell-cell adhesion [TAS]
- positive regulation of T cell proliferation [IDA]
- positive regulation of innate immune response [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PTPRC
Gene Ontology Biological Process
- B cell proliferation [ISS]
- B cell receptor signaling pathway [ISS]
- T cell differentiation [ISS]
- T cell receptor signaling pathway [IDA, TAS]
- axon guidance [TAS]
- bone marrow development [IMP]
- cell cycle phase transition [IMP]
- cell surface receptor signaling pathway [TAS]
- defense response to virus [ISS]
- dephosphorylation [ISS]
- hematopoietic progenitor cell differentiation [IMP]
- immunoglobulin biosynthetic process [IMP]
- negative regulation of T cell mediated cytotoxicity [ISS]
- negative regulation of cell adhesion involved in substrate-bound cell migration [IMP]
- negative regulation of cytokine-mediated signaling pathway [ISS]
- negative regulation of protein kinase activity [IDA, ISS]
- peptidyl-tyrosine dephosphorylation [IDA, TAS]
- positive regulation of B cell proliferation [IMP]
- positive regulation of T cell proliferation [ISS]
- positive regulation of antigen receptor-mediated signaling pathway [ISS]
- positive regulation of hematopoietic stem cell migration [IMP]
- positive regulation of protein kinase activity [NAS]
- positive regulation of stem cell proliferation [IMP]
- protein dephosphorylation [ISS]
- regulation of cell cycle [ISS]
- release of sequestered calcium ion into cytosol [ISS]
- stem cell development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The nonclassical class I molecule CD1d associates with the novel CD8 ligand gp180 on intestinal epithelial cells.
Previous studies have shown that normal intestinal epithelial cells (IECs) are able to selectively activate CD8(+) T cells with suppressor activity, inducing proliferation associated with the activation of both the CD8-associated kinase p56(lck) and the T cell receptor (TCR)-associated kinase p59(fyn). This process appears to relate in part to a 180-kDa IEC surface glycoprotein, gp180, which binds to CD8 and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID