BAIT

LYL1

bHLHa18
lymphoblastic leukemia associated hematopoiesis regulator 1
Homo sapiens
PREY

LMO1

RBTN1, RHOM1, TTG1
LIM domain only 1 (rhombotin 1)
GO Process (1)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.

Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R

The protein products of proto-oncogenes implicated in T cell acute lymphoblastic leukemia include two distinct families of presumptive transcription factors. RBTN1 and RBTN2 encode highly related proteins that possess cysteine-rich LIM motifs. TAL1, TAL2 and LYL1 encode a unique subgroup of basic helix-loop-helix (bHLH) proteins that share exceptional homology in their bHLH sequences. We have found that RBTN1 and RBTN2 ... [more]

EMBO J. Oct. 17, 1994; 13(20);4831-9 [Pubmed: 7957052]

Throughput

  • Low Throughput

Curated By

  • BioGRID