BCL2
Gene Ontology Biological Process
- B cell proliferation [IDA]
- B cell receptor signaling pathway [IMP]
- apoptotic process [IDA, TAS]
- cellular response to DNA damage stimulus [IMP]
- defense response to virus [IDA]
- endoplasmic reticulum calcium ion homeostasis [TAS]
- extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- female pregnancy [NAS]
- humoral immune response [TAS]
- innate immune response [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IBA]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IDA]
- negative regulation of anoikis [IMP]
- negative regulation of apoptotic process [IDA, IMP]
- negative regulation of apoptotic signaling pathway [IMP]
- negative regulation of autophagy [TAS]
- negative regulation of cellular pH reduction [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IGI]
- negative regulation of intrinsic apoptotic signaling pathway [IDA]
- negative regulation of mitochondrial depolarization [TAS]
- negative regulation of neuron apoptotic process [IDA]
- neuron apoptotic process [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- positive regulation of B cell proliferation [IMP]
- positive regulation of cell growth [IDA]
- positive regulation of intrinsic apoptotic signaling pathway [TAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- protein polyubiquitination [IDA]
- regulation of calcium ion transport [IDA]
- regulation of mitochondrial membrane permeability [ISS]
- regulation of mitochondrial membrane potential [ISS]
- regulation of protein heterodimerization activity [IDA]
- regulation of protein homodimerization activity [IDA]
- regulation of transmembrane transporter activity [IDA]
- release of cytochrome c from mitochondria [ISS, NAS]
- response to cytokine [IDA]
- response to drug [IDA, IMP]
- response to iron ion [IDA]
- response to nicotine [IDA]
- response to radiation [NAS]
- response to toxic substance [IDA]
- transmembrane transport [IDA]
Gene Ontology Molecular Function- BH3 domain binding [IPI]
- channel activity [IDA]
- channel inhibitor activity [IDA]
- identical protein binding [IPI]
- protease binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- ubiquitin protein ligase binding [IPI]
- BH3 domain binding [IPI]
- channel activity [IDA]
- channel inhibitor activity [IDA]
- identical protein binding [IPI]
- protease binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
SMN1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy.
Spinal muscular atrophy (SMA) is a motor neuron disease characterized by degeneration of the anterior horn cells of the spinal cord. It is a common fatal autosomal recessive disorder and linkage studies have identified two candidate genes, SMN and NAIP, both on chromosome 5q13. Although NAIP protein is known to have an anti-apoptotic function, the function of SMN has been ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SMN1 BCL2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| SMN1 BCL2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID