BCR
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IL3
Gene Ontology Biological Process
- cell-cell signaling [TAS]
- cytokine-mediated signaling pathway [IBA]
- embryonic hemopoiesis [IDA]
- nervous system development [TAS]
- positive regulation of DNA replication [IDA]
- positive regulation of cell proliferation [ISS]
- positive regulation of mast cell proliferation [IBA]
- positive regulation of myeloid leukocyte differentiation [IBA]
- positive regulation of peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
P210 Bcr-Abl interacts with the interleukin-3 beta c subunit and constitutively activates Jak2.
Chronic myelogenous leukemia is a neoplasm of pluripotent hematopoietic cells. Cytokines such as interleukin-3 and granulocyte-macrophage colony-stimulating factor regulate the growth and differentiation of hematopoietic precursors. These cytokines activate two distinct signals to the nucleus. One signal is through the Ras pathway, and the second involves activation of Jak2. We demonstrated that Bcr-Abl co-immunoprecipitates with and constitutively phosphorylates the common ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID