MMP9
Gene Ontology Biological Process
- collagen catabolic process [TAS]
- endodermal cell differentiation [IEP]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- macrophage differentiation [TAS]
- negative regulation of cation channel activity [IDA]
- positive regulation of keratinocyte migration [IMP]
- positive regulation of receptor binding [IDA]
- proteolysis [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
THBS2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity.
Thrombospondins are thought to function as inhibitors of angiogenesis. However, the mechanism(s) of this activity is not well understood. In this study, we have used the yeast two-hybrid system to identify proteins that interact with the thrombospondins 1 (TSP1) and 2 (TSP2) properdin-like type 1 repeats (TSR). One of the proteins identified that interacted with both TSR was matrix metalloproteinase ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID