CD46
Gene Ontology Biological Process
- T cell mediated immunity [IMP]
- adaptive immune response [IC]
- innate immune response [TAS]
- interleukin-10 production [IDA]
- negative regulation of gene expression [IDA]
- positive regulation of T cell proliferation [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of interleukin-10 production [IDA]
- positive regulation of memory T cell differentiation [IDA]
- positive regulation of regulatory T cell differentiation [IDA]
- positive regulation of transforming growth factor beta production [IDA]
- regulation of Notch signaling pathway [IDA]
- regulation of complement activation [TAS]
- sequestering of extracellular ligand from receptor [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
YES1
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- T cell costimulation [TAS]
- blood coagulation [TAS]
- cell differentiation [IBA]
- cellular protein modification process [TAS]
- cellular response to peptide hormone stimulus [IBA]
- innate immune response [IBA, TAS]
- leukocyte migration [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- regulation of cell proliferation [IBA]
- regulation of vascular permeability [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae.
The Neisseria type IV pilus promotes bacterial adhesion to host cells. The pilus binds CD46, a complement-regulatory glycoprotein present on nucleated human cells (Kaellstroem et al., 1997). CD46 mutants with truncated cytoplasmic tails fail to support bacterial adhesion (Kaellstroem et al., 2001), suggesting that this region of the molecule also plays an important role in infection. Here, we report that ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID