Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Deciphering the cellular pathway for transport of poly(A)-binding protein II.

Calado A, Kutay U, Kuehn U, Wahle E, Carmo-Fonseca M

Poly(A)-binding protein II (PABP2) is an abundant nuclear protein that binds with high affinity to nascent poly(A) tails, stimulating their extension and controlling their length. In the cytoplasm, a distinct protein (PABP1) binds to poly(A) tails and participates in mRNA translation and stability. How cytoplasmic PABP1 substitutes for nuclear PABP2 is still unknown. Here we report that PABP2 shuttles back ... [more]

RNA Feb. 01, 2000; 6(2);245-56 [Pubmed: 10688363]

Throughput

  • Low Throughput

Curated By

  • BioGRID