BAIT
NRP1
C530029I03, NP-1, NPN-1, Npn1, Nrp
neuropilin 1
GO Process (55)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- VEGF-activated neuropilin signaling pathway [IMP]
- VEGF-activated neuropilin signaling pathway involved in axon guidance [IMP]
- angiogenesis [IGI, IMP, ISO]
- angiogenesis involved in coronary vascular morphogenesis [IMP]
- artery morphogenesis [IMP]
- axon extension involved in axon guidance [IMP]
- axon guidance [IDA, IMP, ISO]
- axonal fasciculation [IMP]
- axonogenesis involved in innervation [IMP]
- cell migration [IMP]
- cell migration involved in coronary vasculogenesis [IC]
- cell migration involved in sprouting angiogenesis [IC, IMP]
- cellular response to hepatocyte growth factor stimulus [ISO]
- cellular response to vascular endothelial growth factor stimulus [IMP]
- commissural neuron axon guidance [IMP]
- coronary artery morphogenesis [IMP]
- dendrite development [IMP]
- dichotomous subdivision of terminal units involved in salivary gland branching [IGI, IMP]
- endothelial cell chemotaxis [ISO]
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus [IMP]
- heart development [IGI]
- hepatocyte growth factor receptor signaling pathway [ISO]
- negative regulation of axon extension [IGI]
- negative regulation of axon extension involved in axon guidance [IDA, ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of neuron apoptotic process [IMP]
- nerve development [IMP]
- neural crest cell migration involved in autonomic nervous system development [IMP]
- neuron development [IMP]
- neuron migration [IMP]
- patterning of blood vessels [IMP]
- peptidyl-tyrosine phosphorylation [IMP]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive chemotaxis [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of axon extension involved in axon guidance [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP, ISO]
- positive regulation of retinal ganglion cell axon guidance [IMP]
- protein localization to early endosome [IMP]
- regulation of axon extension involved in axon guidance [IDA]
- regulation of retinal ganglion cell axon guidance [IMP]
- renal artery morphogenesis [IMP]
- retina vasculature morphogenesis in camera-type eye [IMP]
- retinal ganglion cell axon guidance [IMP]
- semaphorin-plexin signaling pathway [IDA, IGI, IPI]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [IMP]
- sprouting angiogenesis [IMP]
- sympathetic ganglion development [IMP]
- sympathetic nervous system development [IMP]
- sympathetic neuron projection extension [IMP]
- sympathetic neuron projection guidance [IMP]
- toxin transport [IMP]
- trigeminal nerve morphogenesis [IMP]
- vascular endothelial growth factor receptor signaling pathway [IMP, ISO]
- vascular endothelial growth factor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SEMA3F
SEMA-IV, SEMA4, SEMAK
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
GO Process (7)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III.
Semaphorins are a large family of secreted and transmembrane proteins, several of which are implicated in repulsive axon guidance. Neuropilin (neuropilin-1) was recently identified as a receptor for Collapsin-1/Semaphorin III/D (Sema III). We report the identification of a related protein, neuropilin-2, whose mRNA is expressed by developing neurons in a pattern largely, though not completely, nonoverlapping with that of neuropilin-1. ... [more]
Neuron Sep. 01, 1997; 19(3);547-59 [Pubmed: 9331348]
Throughput
- Low Throughput
Curated By
- BioGRID