BAIT
CASP2
CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57
caspase 2, apoptosis-related cysteine peptidase
GO Process (11)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [IMP]
- apoptotic process [NAS]
- apoptotic signaling pathway [TAS]
- cellular response to mechanical stimulus [IEP]
- execution phase of apoptosis [TAS]
- extrinsic apoptotic signaling pathway in absence of ligand [IBA]
- intrinsic apoptotic signaling pathway in response to DNA damage [IBA, TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of apoptotic process [IDA]
- protein processing [IDA]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
CCND3
RP5-973N23.3
cyclin D3
GO Process (2)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Cyclin D3 activates Caspase 2, connecting cell proliferation with cell death.
Precancerous cells that enter S phase without appropriate growth and viability factors undergo programmed cell death, suggesting that apoptosis may help guarantee organismic integrity [Evan, G. & Littlewood, T. (1998) Science 281, 1317-1322]. However, the connection between proliferation and cell death has remained unclear. Here, we show that the positive cell cycle regulator cyclin D3 [Matsushime H., Roussel M. F., ... [more]
Proc. Natl. Acad. Sci. U.S.A. May. 14, 2002; 99(10);6871-6 [Pubmed: 12011445]
Throughput
- Low Throughput
Curated By
- BioGRID