BAIT
ERBB2
Erbb-2, HER-2, HER2, Neu, c-erbB2, c-neu, mKIAA3023, RP23-355L10.8
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
GO Process (35)
GO Function (13)
GO Component (15)
Gene Ontology Biological Process
- cell surface receptor signaling pathway [ISO]
- estrus [ISO]
- glial cell differentiation [ISO]
- heart development [IMP]
- motor neuron axon guidance [IMP]
- myelination [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of immature T cell proliferation in thymus [IMP]
- nervous system development [IMP]
- neuromuscular junction development [IMP]
- oligodendrocyte differentiation [IMP]
- peptidyl-tyrosine phosphorylation [ISO]
- peripheral nervous system development [IMP, ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of Ras protein signal transduction [ISO]
- positive regulation of Rho GTPase activity [IMP]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase I promoter [ISO]
- positive regulation of transcription from RNA polymerase III promoter [ISO]
- positive regulation of translation [ISO]
- protein autophosphorylation [ISO]
- regulation of ERK1 and ERK2 cascade [ISO]
- regulation of microtubule-based process [ISO]
- response to axon injury [ISO]
- signal transduction [ISO]
- sympathetic nervous system development [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO]
- wound healing [ISO]
Gene Ontology Molecular Function- Hsp90 protein binding [ISO]
- RNA polymerase I core binding [ISO]
- glycoprotein binding [ISO]
- growth factor binding [ISO]
- identical protein binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
- transmembrane signaling receptor activity [ISO]
- ubiquitin protein ligase binding [ISO]
- Hsp90 protein binding [ISO]
- RNA polymerase I core binding [ISO]
- glycoprotein binding [ISO]
- growth factor binding [ISO]
- identical protein binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
- transmembrane signaling receptor activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- apical plasma membrane [IDA, ISO]
- basal plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic vesicle [IDA]
- endosome membrane [ISO]
- integral component of membrane [NAS]
- lateral loop [ISO]
- membrane raft [ISO]
- microvillus [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic membrane [ISO]
- receptor complex [ISO]
Mus musculus
PREY
ERBB2IP
ERBIN, HEL-S-78, LAP2
erbb2 interacting protein
GO Process (9)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- basal protein localization [NAS]
- cell adhesion [NAS]
- cell cycle [NAS]
- cell growth [NAS]
- epidermal growth factor receptor signaling pathway [TAS]
- establishment or maintenance of epithelial cell apical/basal polarity [NAS]
- integrin-mediated signaling pathway [NAS]
- intermediate filament cytoskeleton organization [NAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95.
Neuregulin is a factor essential for synapse-specific transcription of acetylcholine receptor genes at the neuromuscular junction. Its receptors, ErbB receptor tyrosine kinases, are localized at the postjunctional membrane presumably to ensure localized signaling. However, the molecular mechanisms underlying synaptic localization of ErbBs are unknown. Our recent studies indicate that ErbB4 interacts with postsynaptic density (PSD)-95 (SAP90), a PDZ domain-containing protein ... [more]
J. Biol. Chem. Jun. 01, 2001; 276(22);19318-26 [Pubmed: 11279080]
Throughput
- Low Throughput
Curated By
- BioGRID