BAIT
PSMD10
dJ889N15.2, p28, p28(GANK), RP5-889N15.3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
GO Process (32)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]
- G1/S transition of mitotic cell cycle [TAS]
- RNA metabolic process [TAS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- apoptotic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- cytoplasmic sequestering of NF-kappaB [IDA]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of MAPK cascade [IMP]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of apoptotic process [IDA, IMP, TAS]
- negative regulation of release of cytochrome c from mitochondria [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- positive regulation of cell growth [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA, TAS]
- positive regulation of protein ubiquitination [IMP]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- proteasome regulatory particle assembly [IMP]
- protein polyubiquitination [TAS]
- regulation of apoptotic process [TAS]
- regulation of cellular amino acid metabolic process [TAS]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- small molecule metabolic process [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PTPN2
PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP
protein tyrosine phosphatase, non-receptor type 2
GO Process (34)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- B cell differentiation [ISS]
- T cell differentiation [ISS]
- cytokine-mediated signaling pathway [TAS]
- erythrocyte differentiation [ISS]
- glucose homeostasis [ISS]
- insulin receptor signaling pathway [ISS]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of T cell receptor signaling pathway [ISS]
- negative regulation of cell proliferation [IMP]
- negative regulation of chemotaxis [ISS]
- negative regulation of epidermal growth factor receptor signaling pathway [IMP]
- negative regulation of inflammatory response [ISS]
- negative regulation of insulin receptor signaling pathway [ISS]
- negative regulation of interferon-gamma-mediated signaling pathway [ISS]
- negative regulation of interleukin-2-mediated signaling pathway [IMP]
- negative regulation of interleukin-4-mediated signaling pathway [IMP]
- negative regulation of interleukin-6-mediated signaling pathway [IMP]
- negative regulation of lipid storage [ISS]
- negative regulation of macrophage colony-stimulating factor signaling pathway [ISS]
- negative regulation of macrophage differentiation [ISS]
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway [ISS]
- negative regulation of positive thymic T cell selection [ISS]
- negative regulation of prolactin signaling pathway [ISS]
- negative regulation of tumor necrosis factor-mediated signaling pathway [ISS]
- negative regulation of type I interferon-mediated signaling pathway [IMP]
- negative regulation of tyrosine phosphorylation of Stat1 protein [IDA, IMP]
- negative regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- negative regulation of tyrosine phosphorylation of Stat5 protein [ISS]
- negative regulation of tyrosine phosphorylation of Stat6 protein [IMP]
- peptidyl-tyrosine dephosphorylation [IDA, IMP]
- positive regulation of gluconeogenesis [ISS]
- regulation of hepatocyte growth factor receptor signaling pathway [IMP]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.999999993 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT HCT116 cells CompPASS score = 0.999999993, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTPN2 PSMD10 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| PTPN2 PSMD10 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID