BAIT
DLGAP1
Gkap
discs, large (Drosophila) homolog-associated protein 1
GO Process (3)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
SHANK3
Prosap2
SH3 and multiple ankyrin repeat domains 3
GO Process (33)
GO Function (9)
GO Component (9)
Gene Ontology Biological Process
- MAPK cascade [ISO, ISS]
- N-methyl-D-aspartate receptor clustering [ISO, ISS]
- adult behavior [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISO, ISS]
- brain morphogenesis [ISO, ISS]
- dendritic spine morphogenesis [ISO, ISS]
- embryonic epithelial tube formation [ISO]
- guanylate kinase-associated protein clustering [ISO, ISS]
- learning [ISO, ISS]
- locomotory exploration behavior [ISO, ISS]
- memory [ISO, ISS]
- negative regulation of actin filament bundle assembly [ISO, ISS]
- negative regulation of cell volume [ISO, ISS]
- neuromuscular process controlling balance [ISO, ISS]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISO, ISS]
- positive regulation of dendritic spine development [ISO, ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISO, ISS]
- positive regulation of glutamate receptor signaling pathway [IMP, ISO, ISS]
- positive regulation of long-term neuronal synaptic plasticity [ISO, ISS]
- positive regulation of synapse structural plasticity [ISO, ISS]
- positive regulation of synaptic transmission, glutamatergic [ISO, ISS]
- postsynaptic density assembly [ISO, ISS]
- protein oligomerization [IDA]
- regulation of behavioral fear response [ISO, ISS]
- regulation of dendritic spine morphogenesis [ISO, ISS]
- regulation of grooming behavior [ISO, ISS]
- regulation of long term synaptic depression [ISO, ISS]
- regulation of long-term synaptic potentiation [ISO, ISS]
- social behavior [ISO, ISS]
- striatal medium spiny neuron differentiation [ISO, ISS]
- synapse assembly [ISO, ISS]
- vocal learning [ISO]
- vocalization behavior [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin.
NMDA receptors are linked to intracellular cytoskeletal and signaling molecules via the PSD-95 protein complex. We report a novel family of postsynaptic density (PSD) proteins, termed Shank, that binds via its PDZ domain to the C terminus of PSD-95-associated protein GKAP. A ternary complex of Shank/GKAP/PSD-95 assembles in heterologous cells and can be coimmunoprecipitated from rat brain. Synaptic localization of ... [more]
Neuron Jul. 01, 1999; 23(3);569-82 [Pubmed: 10433268]
Throughput
- Low Throughput
Curated By
- BioGRID