BAIT
HYAL1
HYAL-1, LUCA1, NAT6
hyaluronoglucosaminidase 1
GO Process (27)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- cartilage development [IEP]
- cellular response to UV-B [IDA]
- cellular response to fibroblast growth factor stimulus [IDA]
- cellular response to interleukin-1 [IDA]
- cellular response to pH [IDA]
- cellular response to platelet-derived growth factor stimulus [IDA]
- cellular response to tumor necrosis factor [IEP]
- chondroitin sulfate catabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- glycosaminoglycan metabolic process [TAS]
- hyaluronan biosynthetic process [IDA]
- hyaluronan catabolic process [IDA, TAS]
- hyaluronan metabolic process [IDA, TAS]
- inflammatory response [IDA]
- negative regulation of cell growth [IDA]
- positive regulation of angiogenesis [IDA, IMP]
- positive regulation of cell adhesion [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of epithelial cell migration [IDA]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of growth [IDA]
- positive regulation of hyaluranon cable assembly [IDA]
- response to antibiotic [IDA]
- response to reactive oxygen species [IDA]
- response to virus [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ICAM5
TLCN, TLN
intercellular adhesion molecule 5, telencephalin
GO Process (1)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.979846825 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT HCT116 cells CompPASS score = 0.979846825, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID