GLI1
Gene Ontology Biological Process
- digestive tract morphogenesis [TAS]
- epidermal cell differentiation [IDA]
- negative regulation of canonical Wnt signaling pathway [IMP]
- osteoblast differentiation [IDA]
- positive regulation of DNA replication [IDA]
- positive regulation of cell proliferation [IMP]
- positive regulation of smoothened signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of smoothened signaling pathway [TAS]
- smoothened signaling pathway [IDA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SIN3A
Gene Ontology Biological Process
- DNA replication [IMP]
- activation of innate immune response [ISO]
- aging [ISO]
- cellular protein localization [IMP]
- cellular response to glucose stimulus [IDA]
- hematopoietic progenitor cell differentiation [IMP]
- histone deacetylation [IBA]
- in utero embryonic development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of circadian rhythm [IMP]
- negative regulation of histone H3-K27 acetylation [ISO]
- negative regulation of protein localization to nucleus [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- negative regulation of transcription regulatory region DNA binding [ISO]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of chromatin silencing [ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein deacetylation [ISO]
- regulation of hormone levels [ISO]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [ISO]
- regulation of transcription, DNA-templated [IMP]
- response to methylglyoxal [IDA]
- response to organonitrogen compound [ISO]
- transcription from RNA polymerase II promoter [IGI]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II repressing transcription factor binding [IPI]
- RNA polymerase II transcription corepressor activity [IGI]
- chromatin binding [IDA]
- histone deacetylase activity [IBA]
- protein binding [IPI]
- protein complex binding [ISO]
- protein deacetylase activity [ISO]
- sequence-specific DNA binding transcription factor activity [IMP]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region sequence-specific DNA binding [IDA]
- DNA binding [IDA]
- RNA binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II repressing transcription factor binding [IPI]
- RNA polymerase II transcription corepressor activity [IGI]
- chromatin binding [IDA]
- histone deacetylase activity [IBA]
- protein binding [IPI]
- protein complex binding [ISO]
- protein deacetylase activity [ISO]
- sequence-specific DNA binding transcription factor activity [IMP]
- transcription corepressor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex.
The Suppressor of Fused [Su(fu)] protein plays a conserved role in the regulation of Gli transcription factors of the hedgehog (Hh) signaling pathway that controls cell fate and tissue patterning during development. In both Drosophila and mammals, Su(fu) represses Gli-mediated transcription, but the mode of its action is not completely understood. Recent evidence suggests that Su(fu) physically interacts with the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID