BAIT
GLI3
ACLS, GCPS, GLI3-190, GLI3FL, PAP-A, PAPA, PAPA1, PAPB, PHS, PPDIV
GLI family zinc finger 3
GO Process (16)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- T cell differentiation in thymus [ISS]
- embryonic digestive tract development [TAS]
- embryonic digit morphogenesis [TAS]
- limb morphogenesis [IMP]
- negative regulation of alpha-beta T cell differentiation [ISS]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of smoothened signaling pathway [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative thymic T cell selection [ISS]
- nose morphogenesis [TAS]
- positive regulation of alpha-beta T cell differentiation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [ISS]
- smoothened signaling pathway [TAS]
- thymocyte apoptotic process [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
- beta-catenin binding [IPI]
- histone acetyltransferase binding [IPI]
- histone deacetylase binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
- beta-catenin binding [IPI]
- histone acetyltransferase binding [IPI]
- histone deacetylase binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
Homo sapiens
PREY
SAP18
2HOR0202, SAP18P, GIG38
Sin3A-associated protein, 18kDa
GO Process (5)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- negative regulation of mRNA splicing, via spliceosome [IDA]
- negative regulation of nucleic acid-templated transcription [TAS]
- positive regulation of apoptotic process [IDA]
- regulation of alternative mRNA splicing, via spliceosome [IDA, IMP]
- regulation of transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex.
The Suppressor of Fused [Su(fu)] protein plays a conserved role in the regulation of Gli transcription factors of the hedgehog (Hh) signaling pathway that controls cell fate and tissue patterning during development. In both Drosophila and mammals, Su(fu) represses Gli-mediated transcription, but the mode of its action is not completely understood. Recent evidence suggests that Su(fu) physically interacts with the ... [more]
Proc. Natl. Acad. Sci. U.S.A. Apr. 16, 2002; 99(8);5442-7 [Pubmed: 11960000]
Throughput
- Low Throughput
Curated By
- BioGRID