BAIT
P2RX2
DFNA41, P2X2
purinergic receptor P2X, ligand-gated ion channel, 2
GO Process (8)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- cation transmembrane transport [IDA, NAS]
- cation transport [IDA, NAS]
- ion transmembrane transport [TAS]
- positive regulation of calcium ion transport into cytosol [NAS]
- positive regulation of calcium-mediated signaling [NAS]
- protein homooligomerization [IPI]
- purinergic nucleotide receptor signaling pathway [NAS]
- sensory perception of sound [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LRP6
ADCAD2
low density lipoprotein receptor-related protein 6
GO Process (48)
GO Function (12)
GO Component (9)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA, IMP]
- Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- Wnt signaling pathway involved in somitogenesis [IBA]
- anterior/posterior pattern specification [IBA]
- axis elongation involved in somitogenesis [IBA]
- bone morphogenesis [IBA]
- bone remodeling [IBA]
- branching involved in mammary gland duct morphogenesis [IBA]
- canonical Wnt signaling pathway [IDA, IMP]
- canonical Wnt signaling pathway involved in neural crest cell differentiation [IC]
- canonical Wnt signaling pathway involved in regulation of cell proliferation [IC]
- cellular response to cholesterol [IMP]
- cerebellum morphogenesis [IBA]
- cerebral cortex development [IBA]
- convergent extension [IBA]
- embryonic camera-type eye morphogenesis [IBA]
- embryonic limb morphogenesis [IBA]
- embryonic pattern specification [IBA]
- embryonic retina morphogenesis in camera-type eye [IBA]
- external genitalia morphogenesis [IBA]
- face morphogenesis [IBA]
- gastrulation with mouth forming second [IBA]
- midbrain development [IBA]
- midbrain-hindbrain boundary development [IBA]
- negative regulation of protein kinase activity [IMP]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of protein serine/threonine kinase activity [IDA]
- negative regulation of smooth muscle cell apoptotic process [IMP]
- neural crest cell differentiation [IDA]
- neural crest formation [IDA]
- neural tube closure [IBA]
- odontogenesis of dentin-containing tooth [IBA]
- palate development [IBA]
- pericardium morphogenesis [IBA]
- positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cell cycle [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- primitive streak formation [IBA]
- receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [IBA]
- regulation of fat cell differentiation [IBA]
- regulation of ossification [IBA]
- synaptic transmission [IBA]
- thalamus development [IBA]
- toxin transport [IMP]
- trachea cartilage morphogenesis [IBA]
Gene Ontology Molecular Function- Wnt-activated receptor activity [IBA]
- Wnt-protein binding [IPI]
- apolipoprotein binding [IBA]
- coreceptor activity involved in Wnt signaling pathway [IDA]
- frizzled binding [IPI]
- identical protein binding [IPI]
- kinase inhibitor activity [IMP]
- low-density lipoprotein receptor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- receptor binding [IPI]
- toxin transporter activity [IMP]
- Wnt-activated receptor activity [IBA]
- Wnt-protein binding [IPI]
- apolipoprotein binding [IBA]
- coreceptor activity involved in Wnt signaling pathway [IDA]
- frizzled binding [IPI]
- identical protein binding [IPI]
- kinase inhibitor activity [IMP]
- low-density lipoprotein receptor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- receptor binding [IPI]
- toxin transporter activity [IMP]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.859394269 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT HCT116 cells CompPASS score = 0.859394269, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID