BAIT
TGFBR2
AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGFR-2, TGFbeta-RII
transforming growth factor, beta receptor II (70/80kDa)
GO Process (27)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- activation of protein kinase activity [ISS]
- apoptotic process [IDA]
- blood vessel development [TAS]
- brain development [ISS]
- embryonic cranial skeleton morphogenesis [ISS]
- embryonic hemopoiesis [ISS]
- heart development [ISS]
- myeloid dendritic cell differentiation [ISS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- palate development [ISS]
- pathway-restricted SMAD protein phosphorylation [IDA]
- patterning of blood vessels [ISS]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of B cell tolerance induction [ISS]
- positive regulation of NK T cell differentiation [ISS]
- positive regulation of T cell tolerance induction [ISS]
- positive regulation of cell proliferation [TAS]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of tolerance induction to self antigen [ISS]
- protein phosphorylation [IDA]
- regulation of cell proliferation [ISS]
- response to cholesterol [IDA]
- response to drug [IDA]
- transforming growth factor beta receptor signaling pathway [IC, IDA, IMP, TAS]
- vasculogenesis [ISS]
Gene Ontology Molecular Function- SMAD binding [IDA]
- glycosaminoglycan binding [IDA]
- protein binding [IPI]
- transforming growth factor beta binding [IDA, IPI]
- transforming growth factor beta-activated receptor activity [IC, IDA, IMP]
- transmembrane receptor protein serine/threonine kinase activity [IDA]
- type I transforming growth factor beta receptor binding [IDA, IPI]
- type III transforming growth factor beta receptor binding [IDA]
- SMAD binding [IDA]
- glycosaminoglycan binding [IDA]
- protein binding [IPI]
- transforming growth factor beta binding [IDA, IPI]
- transforming growth factor beta-activated receptor activity [IC, IDA, IMP]
- transmembrane receptor protein serine/threonine kinase activity [IDA]
- type I transforming growth factor beta receptor binding [IDA, IPI]
- type III transforming growth factor beta receptor binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
YES1
HsT441, P61-YES, Yes, c-yes
YES proto-oncogene 1, Src family tyrosine kinase
GO Process (12)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- T cell costimulation [TAS]
- blood coagulation [TAS]
- cell differentiation [IBA]
- cellular protein modification process [TAS]
- cellular response to peptide hormone stimulus [IBA]
- innate immune response [IBA, TAS]
- leukocyte migration [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- regulation of cell proliferation [IBA]
- regulation of vascular permeability [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.95055011 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT HCT116 cells CompPASS score = 0.95055011, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID